Tony Stark is backing a charity racing event in order to burnish the image of Stark Industries. Meanwhile, Kawashima, a race car driver who's suffered career-threatening injuries, is won over by A.I.M./Zodiac who promise him they will heal his injuries if he takes out Tony Stark.

Tony Stark meets Aki, a mysterious young girl with strange powers. Tony is shocked when the girl tells him that she belongs to Zodiac and mentions that she needs Tony, as Iron Man to protect her from Zodiac. Is Aki who she says she is? And even if she is, how can Tony trust her?

"Iron Man is dead!" Dr. Chika Tanaka hears these astounding words from Yinsen's own lips. Meanwhile, the seriously wounded Tony Stark survives with the help of Nagato Sakurai and must devise a way to defeat Dio once and for all. But what awaits the arrival of Iron Man is not only Dio, but also four Iron Man Sigma models as well. How will Tony Stark overcome the hopeless situation he finds himself in?