Tony Stark is accused by Defense Minister Kuroda of trying to avoid controversy by sneaking plutonium into Japan aboard an undefended cargo ship. This ship has been attacked and the plutonium stolen, posing a grave threat. Tony dons the Iron Man armor and vows to retrieve the plutonium and clear his name.

Tony and Dr.Tanaka are wake up on an isolated island with no idea how they got there and no hope of getting off the island. Missing his life-saving arc reactor and without his Iron Man armor, how will Tony and Chika be able to escape? And, who put them there in the first place?

Tony Stark learns the shocking truth behind Zodiac. Iron Man must muster all his remaining strength in order to stop the nefarious ambitions of his greatest adversary, the man behind Zodiac. But, when an familiar face enters the battlefield, will he be able to do what needs to be done?