Carol and Jeanie try to find a home for a schizophrenic architect. Carter signs Benton up for an interview with Vucelich for a prestigious study. Carter and Harper try to find a place to make out. Jenn and Rachel are involved in a car accident; Mark is thrown for a loop when he learns that Jenn has been having an affair with a coworker. Doug dines with his mother. Susan receives $3000 in the mail from Chloe.

The ER staffers are in decidedly unfestive moods as Christmas arrives. Carol's spirits are lifted by a Santa-like patient. Mark is outraged when Jenn decides to stay in Milwaukee over Christmas. Benton and Carter score points with Vucelich when Carter convinces an older gentleman, Ruby, to include his wife in Vucelich's study. Mark gives a deposition in the O'Brien case. The death of a priest threatens to start a gang war. Weaver receives a surprise visit from an African friend. A Holocaust survivor, the victim of a carjacking, brings Chanukah to the ER.

Susan throws herself into her work to escape her stressful personal life, earning recognition from Kerry and Mark, who begins preliminary discussions on next year's chief resident. Carter needs a pedes rotation, and fast, with Doug to graduate med school. Doug takes up with his father's girlfriend. Shep overreacts and attacks an Asian boy interfering at a scene. Mark and Jenn try to discuss their divorce amicably, with unforeseen results. Benton is named Resident of the Year. Harper leaves for an OB rotation at Parkland in Dallas.

Susan visits a psychiatrist to cope with the loss of Little Susie. Jeanie's estranged husband Al checks in the ER complaining of flu-like symptoms, which turn out to be caused by HIV. Shep expects Carol to back his version of events during an official investigation of his behavior. Loretta takes a turn for the worse. Doug discovers that his father has disappeared with a LOT of Karen's money.