Weaver rushes to the aid of her female life partner, Sandy Lopez, when the firefighter is severely injured while working and must now battle for her life. Frightened Weaver whispers hope to Sandy by reminding the victim of their newborn child.

Abby and Kovac discover both the joys and difficulties of raising a newborn; Morris is wrongfully accused of being a child molester; Pratt has his trial-by-fire when he has to handle the ER alone, juggling multiple traumas, teaching duties and a troublesome intern. Neela continues to be the target of her difficult supervisor, and Sam discovers her sons latest extra-curricular activity.

Abby and Sam try to treat an obnoxious, aspiring comedian with mysterious symptoms; Pratt must defend his actions in front of the medical board; Neela scrubs in on a kidney donor transplant; and Morris, as the lone attending, must run a busy ER. Also, Kovac gets a surprising proposal from Abby.

Neela, worn out after being on shift for over 24 hours, has to make a quick decision regarding an accident victim's torn aorta. Sarah's grandparents are in town, and Hank is rushed to the ER after collapsing during an outing. Gates tries to convey to Sam that his feelings for her are serious.