Confident second-year resident Pratt wants to prove his abilities when he works the graveyard shift (11 p.m. to 7 a.m.), but his heroics sometimes backfire. Pratt shows contempt for a man, Ed Gamble, who presents no symptoms of disease but temporarily loses his speech.

Pratt and Kovac clash over a miscarriage-prone young woman, Denny, who arrives to deliver a premature baby. Pratt wants to make heroic efforts to save the unborn child, while Kovac is adamantly against spending vast amounts of money to keep the forever sickly baby alive.

To everyone's amazement, Lewis makes a date to share a home-cooked dinner with the elderly Ben Hollander, her depressed patient who is going blind.

On Thanksgiving Day, a helicopter crash outside the ER leaves several injured, and kills Dr. Romano. Alex tries to bring Sam and Luka together.

Neela helps treat two Amish teens who were in a car crash. Sam argues with Dr. Kovac when he pays too much attention to her son.

Carter returns to County General to hearty welcomes. Although Abby is shocked to learn that Carter's beautiful African girlfriend, Kem, is already pregnant with Carter's child, Abby has moved on with her life as well, going back to medical school.

Abby and Neela are assigned to a month-long rotation in the neonatal intensive care unit where they experience emotional roller coasters while caring for the sick infants.

Dr. Carter's girlfriend makes an impression as she observes ER operations. Dr. Gallant is almost shot during a domestic incident. Dr. Weaver dedicates a center to the memory of Dr. Romano.

Morris streets a patient without getting a psych consult, and the guy steals a tank and heads for County. Gillian is visiting Luka, and Sam's not happy about it. Luka and Sam make up by the end of the day though. A 13-year-old boy has chlamydia. Frank has a heart attack. Corday plays the dating game, going out with two men.

Pratt struggles to diagnose a woman who suffers mysterious chronic seizures. An attractive woman, Campbell, informally accuses flirtatious Pratt of sexual harassment. Abby ponders how to get her contentious patients' attention during her psychiatric department rotation.

Carter takes Kem to the hospital to check on their baby since it's not kicking anymore.