A young couple cope with their baby being premature; Greene and Corday struggle with their relationship.

Dr. Carter is allowed a cautious restart with small steps. An extremely blond Dr. Malucci is very curious who's made Dr. Chen pregnant. Dr. Benton has been written out of all the hospital's systems and is stunned by Dr. Romano. An unfortunate incident at a Science Fiction convention makes it look like scenes from the movie 'Mars Attacks'.

Benton is unable to find a job after Romano negatively influences local hospitals. He reluctantly agrees to accept Romano's demeaning offer of a per diem job at County with no benefits. Kovac and Abby are attacked by a mugger with a steel pipe. Injured, Kovac protects Abby and smashes the robber's head on the ground repeatedly.

Tests reveal that Greene has a brain tumor, but he hides the news from Corday. Corday finds out that she is being sued for malpractice. She also reveals to Greene that she is pregnant. Abby's mother refuses to leave. Abby expresses resentment over her difficult childhood to her mother but resignedly brings her home for Thanksgiving dinner.

Maggie contests Abby's attempt to institutionalize her. Weaver treats a few bizarre patients. When Legaspi returns to work after being exonerated of sexual harassment, Weaver tries to reconcile with her. Benton injures his hand while transporting his former teacher to the hospital and must contend with the teacher's wisecracking elderly buddies.

Cleo and Carla clash after Reese gets hurt while in Cleo's care. Weaver and Kovac cannot save the life of a developmentally challenged woman's only caregiver. Abby goes to a therapy session with Maggie. Later, Abby confesses to Maggie that she is afraid to bear children because they might be bipolar like her mother.

Carter is overwhelmed by patients from a rock concert riot. Benton's former girlfriend is killed in a car accident. Newly promoted to chief resident, Chen panics and misdiagnoses a patient. Kovac angers Abby by flirting with a waitress.

Greene's daughter comes to live with him and Corday. Carter and Abby become more intimate. Chen must prove her skills while saving a baby. Weaver terminates Malucci after witnessing him having sex in an ambulance.

Dr. Susan Lewis arrives, looking for work in the Chicago area again. Greene hires her, over Weaver's objection. Chen nervously attends a risk management review, accompanied by the unforgiving Weaver, to discuss a patient who recently died under Chen's supervision.

Lewis faces a hectic first day back at County General. Benton and Roger become frantic when they can't locate Reese. Carter's grandmother is brought to the emergency room. Carter and Abby deal with inept medical students.

Corday's ordeal, caused by the recent infection-related deaths of several of her patients, worsens when she is closely observed by a stern taskmaster. Corday is outraged when a county investigator accuses her of deliberately euthanizing the patients, who all happened to be elderly.

A new medical student, Michael Gallant, arrives in the ER. He's supposed to be working under Dr. Carter's supervision but his grandmother is unwell. Elizabeth Corday is convinced that other doctors are refusing to work with as a result of the mysterious deaths.

When a torrential rainstorm pounds Chicago, patients deluge the emergency room while Weaver speeds to an accident site. There, she finds a pregnant woman, Vicki lying injured inside a wrecked ambulance while live power lines spark. Fourth-year student Michael Gallant makes a dangerous decision in order to help.

Peter Benton continues his court fight against Reese's stepfather, Roger, who seems to have the upper hand. When a woman is accidentally shot during a gas station robbery, Dr. Corday tries to convince the husband to let them harvest her organs. A 15 year old boxer is brought in with a head trauma after sparring with his older brother. Newlyweds are having trouble when she constantly breaks out in a rash; Carter thinks he knows the cause.

Benton commits perjury on the witness stand in order to gain custody of Reese. When Romano refuses to give him a more even schedule, Peter resigns and seeks a job at the clinic where Cleo is newly employed. Benton is granted custody of Reese and he and Cleo decide to move to the suburbs together. Meanwhile, Carter's father visits for Christmas with the news that he's getting divorced, Weaver and Sandy Lopez finally go on a date, and Abby catches Nicole in the maternity ward, recovering from an abortion.