Sasuke remembers the day that Itachi single-handedly wiped out the entire Uchiha clan as he desperately searches for Naruto. However, Itachi and Kisame have already found him.

Jiraiya and Naruto catch up to Tsunade, whereupon she learns that Konoha wants her to be the 5th Hokage. She refuses the title, angering Naruto, who mistakes her for being a weakling. Naruto learns first-hand how strong she really is. Naruto decides now is the time to try out the Rasengan, only he hasn't perfected it yet.

With Tsunade in her current conidtion, and Jiraiya still under the effects of the drug, Tsunade and Jiraiya must work together to defeat Orochimaru. And with all three ninja having summoned their signature beasts, it's sure to be one heck of a battle!

Naruto, Sakura and Sasuke find out their newest mission will be without Kakashi who has responsibilities elsewhere. Tsunade sends them to the Tea Country to protect someone, but the details are vague at best. Along the way they meet Idate Morino who causes the group a lot of trouble, especially when they discover who they have to protect!

As their rivalry reaches a fever pitch, Kakashi-sensei breaks up the battle and sends Naruto and Sasuke to their corners. Meanwhile, Four Sound ninja enter the Hidden Leaf Village with only one thing on their mind... Sasuke!

Hot on Sasuke's trail, Shikamaru and his squad get caught up in a web of unparalled chakra when they tangle with the six-armed Kidomaru!

With the Sasuke retrieval squad now split into individual battles, it's up to Naruto, Kiba and Shikamaru to stop the sound ninja. But little do they realize that there's more to their opponents than their basic techniques.