Jiraiya and Naruto begin their search for Tsunade, but are constantly sidetracked by Jiraiya's peeping and hitting on pretty girls. Jiraiya tells Naruto some stories about the 3rd and 4th Hokages. Meanwhile, Sasuke learns that his brother, Itachi, is after Naruto and goes to warn him.

Naruto makes a bet with Tsunade, that if he can master the Rasengan in one week, she'll give him a necklace belonging the to the First Hokage. However, Shizune reveals some startling information. Everybody, except for Tsunade, who's worn that necklace has died the next day!

Konohamaru locks himself in the office used by the 3rd to stop them from replacing his grandfather, the previous Hokage. Tsunade spends the day locked out of her office and researches a way to heal Rock Lee so he has a better chance of surviving the operation,

Down for the count and at the mercy of the Sound Ninja, Kiba, Shikamaru and Rock Lee get help from an unlikely bunch of new allies.