Doherty, riding on his motorcycle, is first to arrive at a multivehicle collision; Taylor is hit by a car; Tatiana goes to see Chevchenko, and tragedy ensues.

Doc supervises a new paramedic on her first day; Carlos is arrested after a teenaged patient accuses him of molesting her; Bosco and Faith search for an escaped prisoner; Sully and Davis team up with fire and EMS to save construction workers when their scaffold collapses; in the aftermath of the bank robbery, Faith is troubled when Emily asks her how many people she's killed in the line of duty.

As she keeps vigil by Emily's bedside, Faith recalls her first days at the Police Academy and the beginning of her friendship with Bosco; the fire squad rescues Bosco, Maritza, and a very pregnant Linda Barnes from the inferno, but Lettie Cruz succumbs to her drug binge before they can reach her; Emily is released from the hospital and takes responsibility for her overdose; Bosco tracks down Gary Barnes with Linda's help; Maritza and Bosco's relationship goes to a new level when he attempts to comfort her on the lost of her sister; Kim finally testifies before the review board and stands up for Carlos.

Doc is demoted back to the streets and continues his downward spiral, presenting Kim with no end of problems as he lies about his demotion, resists her orders as the supervising paramedic, and deliberately runs down a perp with the bus; Barnes is shanked at Riker's for doing a flip on Buford; Carlos is devastated when Kylie is diagnosed with aplastic anemia and he's not a match for a bone marrow donation; Sully tries to deflect Ty's teasing about his relationship with Barbara by getting him to focus on their LSAT prep; after a horrific gunfight, Maritza finally captures Lettie's killer and decides to spare him so that he can suffer for the rest of his life in prison.

The news that Faith is repartnering with Bosco outrages Fred; Bosco overcomes his initial wariness about his brother's claims of sobriety after the tip Mikey gives him about Ecstasy dealers leads to a solid bust; in the wake of the hostage situation, the department shrink sent to debrief the house elicits a range of emotional reactions from Kim, Carlos and Holly as she reveals that Doc is in the Bellevue psych ward on a suicide watch, and that the toll of 9/11 and its aftermath may be at the root of his collapse; when she investigates the murder of an Ecstasy dealer outside a rave, Maritza discovers that the motive may be a turf war between rival dealers; Bosco is distraught when Maritza informs him that the evidence points to Mikey's being a major Ecstasy dealer who used him to eliminate the competition by providing the tip that lead to the raid; Bosco and Maritza set out separately to find Mikey; tragedy occurs when Maritza and Dade pull over Mikey's car outside a rave.

Faith gets an earful from her daughter for not being around, and discovers that Emily's decision not to attend her mother's promotion ceremony was calculated to drive home a point about all the events Faith missed over the years; Finney threatens to blow Sasha's cover if she doesn't get the goods on Maritza; Sully and Sasha get more than they bargained for when they investigate a domestic and discover a decomposing corpse in the apartment directly above the quarreling couple, leading Sully to teach Brendan a lesson about the less glamorous aspects of police work; starting her career as a detective by partnering up with Jelly, Faith pursues her hunch that there's something more to what appears to be a simple suicide, and uncovers the deceased's plan to commit murder with a mail bomb; Grace teases Carlos about dating Holly, while expressing some interest in Brendan; Ty tries and fails to get more information from an uncooperative Sully after Brendan tells Ty that their fathers and Sully

Sasha anonymously slips Ty the I.A.B. file on the cover up of his father's death; Faith visits Bosco and lets him know how much she misses having him for a partner; Sully bristles at being partnered with Brendan; Faith learns a hard lesson about good detective work when she lets herself get hoodwinked into acting on prejudice and ill-informed assumptions in arresting an innocent man for the death of a pregnant Muslim teenager; Brendan and Grace decide to start over and take their relationship along slowly; after Ty reaches out to exactly the wrong person in the department's top brass to uncover the truth behind his father's death, Finney sets the stage for letting Ty know about Sasha's I.A.B. assignment and threatens them both if they continue with their investigations; Fred gets custody of Charlie and Emily agrees to live with Faith; Sully pursues his options on coming forward about Ty Sr.'s death; Brendan once again single-handedly rushes to the rescue to prevent a suicide.

Cruz and Santiago try to track down a gang member who murders witnesses to his murders. Grace finds her mother, who doesn't seem to welcoming.