The news that Faith is repartnering with Bosco outrages Fred; Bosco overcomes his initial wariness about his brother's claims of sobriety after the tip Mikey gives him about Ecstasy dealers leads to a solid bust; in the wake of the hostage situation, the department shrink sent to debrief the house elicits a range of emotional reactions from Kim, Carlos and Holly as she reveals that Doc is in the Bellevue psych ward on a suicide watch, and that the toll of 9/11 and its aftermath may be at the root of his collapse; when she investigates the murder of an Ecstasy dealer outside a rave, Maritza discovers that the motive may be a turf war between rival dealers; Bosco is distraught when Maritza informs him that the evidence points to Mikey's being a major Ecstasy dealer who used him to eliminate the competition by providing the tip that lead to the raid; Bosco and Maritza set out separately to find Mikey; tragedy occurs when Maritza and Dade pull over Mikey's car outside a rave.

Wary of Lester Martin, the high-priced lawyer his father has found for Mikey and the deal he's attempting to broker, Bosco warns his brother to stay away from Maritza, but Mikey decides to disregard his brother's advice and makes a deal to become her informant; for good measure, Bosco threatens to kill Maritza if anything happens to Mikey; Sully teases Ty about his budding relationship with Sasha; Faith and Bosco strike a deal with Laura, who also has no love lost for Maritza, to protect Mikey by helping her nab the drug dealers before Maritza gets to them; J.D. offers Kim a ride home, but stops off first at a rave that both Anti-Crime and Narcotics have staked out, thanks to information Mikey gave them; when some bad ecstasy begins to take a rapid toll, the paramedics call for backup, which prompts Maritza and her detail to storm the building; after an arsonist lobs a Molotov cocktail into the crowded building, Faith and Bosco give chase and capture him, while the firefighters rescue

The Boscorelli family suffers a tragic loss at the hands of Donald Mann, who blames Bosco, Faith and Maritza for the death of his son in a high-speed chase; the Yokas family heads off in different directions; the Martin family splits apart into separate jail cells for the parents, and a return home for Rebecca to the mother from whom she was stolen as an infant; the paramedic family at the 55 gets a new member, Grace Foster, which makes no one involved very happy.

Faith begs Fred to return home, but he refuses for a reason that infuriates his wife; Bosco turns a cold shoulder to Maritza's attempts to offer her condolences; Carlos is spectacularly unsuccessful in his attempts to hit on Grace; on the day of his son's funeral, Donald Mann exacts his revenge with the help of a dirty cop by planting bombs designed to kill the police officers he holds responsible for the death of his son; after Mann's lieutenants force a man to crash a car carrying a live bomb into the funeral home where Mikey's wake is being held, Grace takes charge and goes out of protocol to save Rose's life, and Dr. Fields later swears to have her job for it; Kim's decision not to enter the funeral home while the bomb is still live stems not from cowardice, but from maternal instincts; when Mann discovers that some of his intended targets survived the bombings, he sends machine-gun wielding minions into the hospital to finish off the job.