John plots his revenge after being the repeated target of practical jokes. A man breaks his back falling off a tower. A woman fakes an illness. Dr. Early's stethoscope becomes lodged in his ear. A man brought into the hospital from a movie set is the first indication of an outbreak of botulism. A boy is trapped in a condemned building.

Reed and Malloy rush 8-year old Jimmy to Rampart Emergency Hospital with an as yet undiagnosed illness. Upon arrival, the immediate conclusion, and diagnosis are the same: Diabetes.

Scared of the hospital, Jimmy runs off, and it's up to Reed and Malloy to find him before he goes into a diabetic coma. They follow the only lead they have, to the one happy place he was before the attack began, at the pet store, to buy a puppy.

Elsewhere, Malloy's new girlfriend, Cathy, mans a hospital telephone hotline, which is about to go under due to lack of funds. One call has her worried, that from Sherry, a 15-year old junkie threatening suicide to escape her troubled life. Sherry won't discloes where she is while she takes some "reds," supplied by her similary junike mother.

Malloy and Reed need to find her fast, before she OD's.

Squad 51 C-shift paramedics rescue a stuntman from a tower. Gage and Desoto respond to treat the injured child of a fireman's widow. A small plane and a chartered jetliner collide in midair, landing in a residential neighborhood, trapping Johnny and Roy. Station 18 leads a massive response from Battalion 14 and the Compton city fire department. Dr. Morton heads up a triage team from Rampart. Multiple rescues include passengers from both planes and people in the subdivision. Dr. Early performs brain surgery on the injured child. An elderly man's dog leads Chief McConnike to its owner.