Charlie accurately predicts where a band of bank robbers will strike next. But when Don and his team confront them, a massive shoot-out occurs leaving four people, including an officer, dead. The outcome disturbs Charlie and he retreats into the family garage to work out an unsolvable math problem that he also plunged into after his mother became ill a year earlier. But Don needs his brother's help and tries to get Charlie to return to the case.

Various people in the L.A. area with seemingly nothing in common start to become extremely sick and die on the same day. Don fears bioterrorists may have released a deadly virus into the environment. While he tries to discover whether anyone is behind the outbreak, Charlie tries to locate the point of origin.

Don and the rest of the team find themselves in the midst of a confusing case. The investigation into a missing painting turns grim as a murder plot surfaces. Add Nazis to the mix, and things take an even more interesting turn!