A pit stop at a liquor store leads to a deadly standoff for bank robbers Seth and Richie Gecko, who are making a run for the Mexican border.

Richie's visions intensify as the Gecko Brothers escape the liquor store with dogged lawman Freddie Gonzalez in close pursuit.

The Gecko brothers attempt to leave the hotel and take the Fuller family hostage, but Freddie arrives and complicates the situation.

Gecko brothers and the Fuller family are watching the Santanico Pandemonium as Ranger Freddie Gonzalez shows up to exact revenge.

Three months after freeing Santanico from the Titty Twister, the Gecko Brothers are still on the run; Seth and Kate are lost in Mexico; Richie and Santanico plot vengeance on the culebra Lord.

Seth and Santanico clash with Richie over his betrayal, while Carlos and Scott aim to take Malvado’s empire and unleash culebra frenzy on the world.

Seth and Richie seek help from Santanico Pandemonium, only to discover she’s the target of the Xibalban leader, an ancient queen who has taken on a familiar form. Meanwhile, Freddie and Ximena follow a trail of massacres to a deadly confrontation with Brasa.