Ryuko is awake and she's not happy. Intent on killing Ragyo and Nui, she heads out, leaving her allies behind. Without her power, Nudist Beach must decide what their next step is, but a new piece of intel spurs them to action!

The ongoing battle presses towards Honnouji Academy, but Ragyo and the Original Life Fiber stand in the way. Ryuko and Satsuki set off to face them, leaving Nudist Beach's defense to... Mako?! Meanwhile, a crazed Nui continues working feverishly...