Jay Garrick, a mysterious man from Earth-2, appears at S.T.A.R. Labs with a dire warning about an evil speedster named Zoom, who is set on destroying The Flash. Barry and the team must decide if they can trust this stranger even as they face yet another powerful meta-human. Meanwhile, Joe must deal with a determined officer named Patty Spivot who wants to join his meta-human task force.

Barry and the team look for another Firestorm match for Dr. Stein. When the team meets Jefferson "Jax" Jackson, Caitlin has her reservations about whether Jax is the right match for Dr. Stein. Iris surprises Joe while Barry and Patty grow closer.

After recent events, Barry decides it’s time to confront Zoom and comes up with a dangerous plan. Caitlin sides with Jay and deems it too dangerous for Barry to engage with the speed demon. However, Iris shows her support and brings forth a surprising ally. We see what Earth-2 Harrison Wells’ life was like before coming through the breech.

Vandal Savage arrives in Central City and sets his sights on Kendra Saunders. After Vandal attacks Kendra and Cisco, they turn to Barry for help. Realizing how dangerous Vandal is, Barry takes Kendra to Star City and asks Oliver and team to hide her until he can figure out how to stop Vandal. However, things quickly go from bad to worse when a man with wings AKA Hawkman shows up and flies off with Kendra. Meanwhile, Harrison develops a serum to make Barry run faster and asks Jay to test it out.

The crossover continues on Arrow S04E08 Legends of Yesterday (II).

Now that they've grown closer, Barry considers telling Patty that he is The Flash. Meanwhile, Joe and Iris try to get to know Wally, and the team hunts down a meta-human who can slow time itself.

Barry teams up with Wells to figure out a way to close the breaches, but they are distracted by a meta-human nicknamed Tar Pit who can transform into liquid asphalt. Iris is concerned for Wally’s safety after she finds out about his drag racing hobby. When he refuses to stop she makes a bold move that puts her in danger.

On Earth-2, the team races to find Zoom's lair and asks for help from the most unexpected source. Meanwhile, back on Earth-1, Caitlin rushes to perfect Velocity-9 so that Jay can stop the Geomancer.

Having arrived in town intent on creating maximum chaos, Trajectory's antics are misinterpreted as having been perpetrated by the Flash himself. Barry thus must quickly uncover the mystery of who is the girl under the mask — as well as what is driving her mad desire for speed and destruction.

Equipped with the tachyon device, Barry believes he is fast enough to stop Zoom and wants to open the breaches to catch him. Harry strongly advises against that plan but after Barry convinces him, Harry reveals that Cisco has the power to re-open the breach. Meanwhile, Hunter Zoloman’s painful story on Earth-2 is revealed.

Zoom arrives back on Earth-1 intent on taking over Central City. Barry and Wells come up with a plan to stop Zoom once and for all but it’s extremely dangerous. Unsure if he should take the risk, Barry reaches out to both fathers for advice. Henry is adamantly opposed to Barry risking his life again but Joe thinks he can handle it which puts the two men at odds with each other. Meanwhile, Cisco is shocked when he vibes the Earth-2 villain Rupture, who happens to be his brother Dante’s doppelganger. Rupture came to this Earth seeking justice for Reverb’s death. Iris decides she’s finally ready to open up to Barry about her feelings for him.

After Zoom unleashes an army of Earth-2 meta-humans on Central City, Barry is shaken when he sees their leader is the Black Canary’s Earth-2 doppelganger, the Black Siren. Meanwhile, Wally takes to the streets to help The Flash stop the meta-humans, which worries Joe. Iris and Henry are concerned about Barry taking on Zoom.

Barry realizes the effects from Flashpoint are much greater than he thought. Meanwhile, Barry meets new co-worker Julian Albert and is surprised by Julian's immediate disdain for him.

When aliens called the Dominators attack Central City, Barry speeds over to Star City to ask the Green Arrow for help in stopping them. Realizing the battle against the Dominators is bigger than they thought, they track down the Legends of Tomorrow, and Barry and Cisco create a breach to bring back a secret weapon – Supergirl. Once all of the super friends are assembled, they come up with a plan to attack but a shocking secret related to Flashpoint is revealed and suddenly no one is sure who they can trust. Meanwhile, Wally wants to join the battle against the aliens but Iris tells him he’s not ready.

The crossover starts on Supergirl S02E08 Medusa (I). It continues on Arrow S05E08 Invasion! (III) and DC's Legends of Tomorrow S02E07 Invasion! (IV).

Barry is tormented by his vision of the future where Iris is murdered by Savitar. When a criminal named Plunder shows up in Central City, Barry recalls the villain’s presence in his vision of the future and fears that if he catches Plunder, it will cement Iris’ fate. Confused about Barry’s hesitation to stop Plunder, Wally decides to step in as Kid Flash. Caitlin offers Julian a job.

When Jesse Quick informs the team that her father has been abducted, Barry, Caitlin, Cisco and Julian voyage to Earth-2 on a rescue mission to save Harry from Gorilla City. As they trek through the forest, Barry and the team are immediately captured and brought to Grodd. Grodd tells them he needs their help to stop Solovar, the leader of Gorilla City, as Solovar wants to invade Earth-1. Meanwhile, back on Earth-1, Jesse and Kid Flash hit the streets to stop a metahuman that can control gravity, with H.R. and Joe guiding them from S.T.A.R. Labs.

When Grodd and his army of gorillas bring the battle to Earth-1, The Flash and team must find a way to stop them before they destroy Central City. Gypsy returns to join the fight. Meanwhile, Jesse Quick decides she wants to stay with Wally on Earth-1.

Desperate to stop Savitar and save his friends, Barry turns to the Speed Force for answers. H.R. gives Jesse some advice.

The Flash fights a villain from Earth-19 called Abra Kadabra, who offers to reveal Savitar's identity in exchange for his release.

Barry and the team meet Tracy Brand, a scientist, who may be the key to stopping Savitar. Unfortunately, Killer Frost is also after Tracy so Team Flash must battle their old friend, which proves to be particularly difficult for Cisco. Joe and Cecile’s relationship takes a big turn.

With only 24 hours left until Savitar murders Iris, Barry struggles to save the woman he loves and makes the choice to use any means necessary to do so. Realizing he has one option left to save her, The Flash turns to Captain Cold for help.