Dr. Rhodes must confront his past when he treats a close family friend who's been impaled by glass in a case that reunites him with his sister. Meanwhile, a musician must decide to undergo surgery that will save her life but could destroy her hearing.

The doctors treat victims of a movie-theater shooting as Sharon Goodwin tries to keep the press at bay. A teen with an eating disorder is treated, but Dr. Charles' methods rub others the wrong way. The staffers deal with a racist patient.

A member of Firehouse 51 clings to life and takes a sudden turn for the worse as medical staffers race to give treatment. Meanwhile, Dr. Natalie Manning prepares for her pregnancy and members of Chicago P.D. probe the case of a woman pulled from a fire.

The crossover starts on Chicago Fire S04E10 The Beating Heart (I). It continues on Chicago P.D. S03E10 Now I'm God (III).

Sharon Goodwin puts her job on the line for a patient in need of a lifesaving bone-marrow transplant. Meanwhile, April cares for a homeless man, Dr. Manning's parents arrive, and a couple are injured during their first date by a hit-and-run driver.

Dr. Manning returns from maternity leave and treats a teen with a history of medical issues. Meanwhile, Dr. Choi cares for a former Navy shipmate; a Saudi prince arrives for a surgical procedure, but only from a hotshot surgeon; and a romance blooms between Sarah and a lab tech.

Dr. Halstead jeopardizes his career when he goes against a family's order regarding a terminally ill cancer patient. Meanwhile, April and Dr. Reese treat a homeless man, and Choi's personal issues emerge while caring for a bipolar patient.

A 9/11 hero is treated, but an unforeseen medical problem arises. Meanwhile, Sarah contemplates which hospital to select for her residency; Dr. Choi cares for an injured teen hockey player with a demanding father; and Halstead and Manning clash.

Dr. Rhodes and Dr. Choi clash over the final decision made by a dying patient. Meanwhile, a pending lawsuit against Dr. Halstead moves forward, and doctors race to save a patient with a misdiagnosed flesh-eating bacterial disease.