A 9/11 hero is treated, but an unforeseen medical problem arises. Meanwhile, Sarah contemplates which hospital to select for her residency; Dr. Choi cares for an injured teen hockey player with a demanding father; and Halstead and Manning clash.

A husband makes a request following his wife's death; Dr. Charles tries to reason with a patient who wants to remove his own arm from his body; a child arrives at the hospital after swallowing magnets; Sarah has last-minute thoughts about her residency.

Dr. Rhodes and Dr. Downey clash over how to treat a patient with various health and heart issues. Meanwhile, excessive hoarding at a home comes into play when trying to help a man with a leg injury; a patient is bitten by her own dog; and a commission pays a surprise visit to evaluate the hospital.

Dr. Rhodes treats his mentor and Goodman faces personal issues in the Season 1 finale. Also: April deals with a disorderly patient; Dr. Manning's past catches up with her; and Sarah's graduation day arrives, but she remains conflicted about her future.

Dr. Manning and Jeff Clarke are forced to figure out a mystery illness when an Indonesian man who doesn't speak English arrives at the hospital in dire straights. Maggie takes Dr. Halstead to her family reunion. Dr. Rhodes takes on a complicated heart surgery without consulting Dr. Latham. Dr. Reese and Dr. Charles encounter a woman experiencing an unusual pregnancy.

Dr. Halstead and Dr. Manning deal with two warring brothers who are brought together when one finds himself in desperate need of a kidney. Dr. Reese's former patient Danny comes to a crossroad. Dr. Rhodes and Dr. Latham treat a 16-year-old girl with a genetic condition in need of surgery, but whose overprotective mother disagrees with that course of action. A convict with unusual intentions puts himself in the hospital and Dr. Charles meddles in his daughter Robyn's personal life, much to her dismay. Meanwhile, Dr. Halstead and April make a discovery that complicates her treatment for TB.