The grand opening of Chicago Med's emergency department is interrupted by victims of an elevated train crash, pushing the staff to their limits.

Dr. Choi treats a teen mother who abandoned her newborn baby in an alley, as the staffers must make difficult decisions about the teen's future. Also, a hypochondriac with chest pains is treated, as is a patient suffering from possible dementia.

A member of Firehouse 51 clings to life and takes a sudden turn for the worse as medical staffers race to give treatment. Meanwhile, Dr. Natalie Manning prepares for her pregnancy and members of Chicago P.D. probe the case of a woman pulled from a fire.

The crossover starts on Chicago Fire S04E10 The Beating Heart (I). It continues on Chicago P.D. S03E10 Now I'm God (III).

Sharon Goodwin puts her job on the line for a patient in need of a lifesaving bone-marrow transplant. Meanwhile, April cares for a homeless man, Dr. Manning's parents arrive, and a couple are injured during their first date by a hit-and-run driver.

Dr. Halstead jeopardizes his career when he goes against a family's order regarding a terminally ill cancer patient. Meanwhile, April and Dr. Reese treat a homeless man, and Choi's personal issues emerge while caring for a bipolar patient.

Dr. Rhodes and Dr. Choi clash over the final decision made by a dying patient. Meanwhile, a pending lawsuit against Dr. Halstead moves forward, and doctors race to save a patient with a misdiagnosed flesh-eating bacterial disease.

Nurse Lockwood gets arrested when she takes a stand. Meanwhile, Dr. Halstead deals with a pending lawsuit against him; a baby's injuries come into question; Dr. Charles faces personal issues; and suspicions rise about a patient who was hit by a car.

A husband makes a request following his wife's death; Dr. Charles tries to reason with a patient who wants to remove his own arm from his body; a child arrives at the hospital after swallowing magnets; Sarah has last-minute thoughts about her residency.

An erratic patient arrives, claiming that his heart is pounding inside his head as he takes drastic measures to stop it. Also, Dr. Manning helps a boy with a broken wrist, but she suspects deeper issues exist; Dr. Rhodes impresses with his skills; and Will receives news about a lawsuit.

A teen patient with abdominal pain firmly refuses any drugs. Meanwhile, Dr. Halstead reconnects with his past when treating a patient; a pregnant woman does everything in her power not to deliver the child; and Dr. Rhodes tries to avoid family issues.

April and Dr. Halstead clash over how to treat an alcoholic homeless man with a broken leg. Also, Dr. Manning continues to grieve over her husband's death; two elderly women with the same symptoms share a surprise link; Halstead mulls over a job offer in California.

Dr. Rhodes treats his mentor and Goodman faces personal issues in the Season 1 finale. Also: April deals with a disorderly patient; Dr. Manning's past catches up with her; and Sarah's graduation day arrives, but she remains conflicted about her future.

Dr. Rhodes begins a fellowship in cardiothoracic surgery, only to have problems with his new boss. Dr. Choi is the new chief resident. Dr. Charles approaches Sarah with an interesting opportunity that catches her off-guard. April faces her recently discovered illness.

Several patients are discovered to have the same rare infection, prompting Dr. Charles' daughter Robyn, an epidemiologist, to be brought in to find the common link. Dr. Choi and Dr. Rhodes work on an elderly man who is discovered to be very ill, but a conflict in how to best treat him develops between his son and his young girlfriend. Meanwhile, Dr. Reese tries to help a young drug addict and Maggie tends to a patient who is dear to her heart.

A car accident that occurs at the Chicago Marathon leaves a victim in critical condition and tests the mettle of Dr. Halstead, April and her fourth-year medical resident brother Noah, who must perform a difficult procedure in the field. A mother brings in her 8-year-old girl experiencing a sudden hearing loss and Dr. Manning is left to tend to the case, which takes a complicated turn. Dr. Choi deals with Olga, a woman who is malnourished, prompting him to bring in Dr. Charles to help assess the case. Meanwhile, Goodwin takes measures to get her personal life in order.

Sharon Goodwin's childhood sweetheart arrives at the hospital, but finds himself in dire straits. To help get his financial footing, Dr. Halstead gets lured into a concierge doctor app idea. Meanwhile, a young woman with a heart infection is treated by Dr. Rhodes against Dr. Charles' advice and Reese's former patient, a sex trafficking victim, reaches out to her for help.

Dr. Halstead and Dr. Manning deal with two warring brothers who are brought together when one finds himself in desperate need of a kidney. Dr. Reese's former patient Danny comes to a crossroad. Dr. Rhodes and Dr. Latham treat a 16-year-old girl with a genetic condition in need of surgery, but whose overprotective mother disagrees with that course of action. A convict with unusual intentions puts himself in the hospital and Dr. Charles meddles in his daughter Robyn's personal life, much to her dismay. Meanwhile, Dr. Halstead and April make a discovery that complicates her treatment for TB.

Goodwin tasks Dr. Charles with evaluating a patient as a possible heart recipient, while Jeff makes a confession to Dr. Manning. Dr. Choi deals with two MMA fighters who are brought into Chicago Med in bad shape. Elsewhere, Dr. Stohl returns to the hospital from his sabbatical leave and immediately offers up different medical opinion regarding the treatment of a patient under the care of Dr. Halstead. April discovers her TB medication may lead to further complications.

Dr. Rhodes and Dr. Charles' heart transplant patient gets into a car crash, revealing issues that could complicate her surgery. A past arrest causes trouble for Maggie when the arresting officer is brought to Chicago Med with a serious injury. Elsewhere, Dr. Manning and Dr. Halstead must defend their actions when explaining a patient's cause of death. Meanwhile, Dr. Halstead attempts to treat an uncooperative horse jockey.

It's a long night on the graveyard shift at Chicago Med, especially for Dr. Reese, who must deal with pronouncing patients dead on more than one occasion. April gets called in to work, much to the dismay of Tate, who pressures her to slow down. Meanwhile, Dr. Charles passes along some vital news to Dr. Latham, and Goodwin asks Dr. Rhodes to work on a most unusual patient.

Dr. Manning and Dr. Charles treat a teenage girl with a rapidly changing set of symptoms that has everyone perplexed. Dr. Choi and medical student Jeff Clark encounter a 19 year-old tough guy who is brought into the hospital in severe distress. Once they establish the cause of the pain, the situation quickly turns dangerous and a resolved Dr. Reese does her best to help. Dr. Halstead must deal with a difficult case that is further complicated by Dr. Stohl, who has a camera crew following him around to shoot a promotional video spotlighting the hospital.

Dr. Rhodes convinces Dr. Latham to join him for a medical trip out of town. Dr. Manning treats an 8 year-old cancer patient who wants to give up on his battle. Elsewhere, an unhealthy woman with heart problems is brought in and doesn't want to listen to doctors. Meanwhile, Dr. Choi, Dr. Charles and Dr. Reese work on a complicated case involving a woman with a personality disorder.

Chicago Med braces for an influx of trauma patients when a pre-dawn pileup finds the hospital in full scramble mode. As a result of the storm and emergencies, supplies become limited and Goodwin, Dr. Manning and Dr. Halstead must deal with making an impossible decision. Meanwhile, Dr. Choi handles a severely burned patient who has one final request and Dr. Charles deals with an agitated patient.

It's a miracle when a trauma patient survives the trip to the hospital, putting the pressure on Dr. Rhodes to keep the man alive. Dr. Choi and Dr. Manning have difficulty diagnosing the location of infection in a paralyzed patient. Dr. Reese must find purpose for a grieving widower who relies on a superhero costume. Meanwhile, April pushes Dr. Halstead to use unproved medications to help a patient with no other options.

Dr. Reese is contacted for help by a troubled teen in a psychiatric facility and Dr. Manning tries to help parents make a decision about their comatose daughter's surprise pregnancy. April begins to deal with repercussions from her personal life. Meanwhile, Dr. Choi and Dr. Rhodes work to save both a young girl from Ecuador who collapsed mid-flight, as well as her mother, who made great sacrifices for her daughter.

Will is troubled with a moral decision when his former teacher, Dr. Bella Rowan, is faced with a life-threating disease. Dr. Rhodes and Dr. Bardovi get involved in a sensitive situation when Rhodes disagrees with the father of a young patient regarding a risky procedure. Dr. Charles and Sarah handle an unusual case with a pilot that causes Sarah to have memories of Jason Wheeler's suicide. Maggie takes an aggressive approach to training a new nurse.

The doctors and nurses of Chicago Med find themselves on high alert when an overflow of patients are rushed into the doors following a terrifying apartment complex blaze. Dr. Rhodes fights to save the life of one of Chicago Fire's own, while Dr. Halstead and his brother Jay struggle with their own personal battle.

The crossover starts on Chicago Fire S07E02 Going to War (I). It continues on Chicago P.D. S06E02 Endings (III).

When things become complicated, Will is forced to lie to Natalie. Ethan and April find out some compromising information about Emily's boyfriend and Ava is unsure of what to do with a patient who is refusing treatment.

Dr. Manning and Dr. Halstead become skeptical of a patient's injuries when the victim of a car accident is brought into the hospital. Ethan and April have a difficult time understanding Emily's attachment to her boyfriend despite recent developments. Will and Natalie brace for their joint bachelor/bachelorette party.

The hospital is forced to evacuate when a toxic chemical is brought into the E.D., leaving patients and the staff in grave danger. Stuck in an elevator, Dr. Charles and Dr. Manning are forced to take drastic measures with a pregnant woman. Goodwin is tasked with making difficult choices and Dr. Rhodes discovers a secret that Dr. Bekker has been holding from him.

Dr. Charles struggles to convince Dr. Choi that surgery isn't always the answer. Dr. Rhodes finds himself in hot water with Goodwin when he disobeys her direct order. April becomes frustrated with Maggie when she continues to question her leadership role as the stand-in charge nurse. Dr. Manning suspects Dr. Halstead is keeping something from her.

Will and Natalie prepare for their big day, but an unsuspecting Will soon finds himself sidetracked. Dr. Charles disagrees with Goodwin on how to best handle a patient's treatment while Dr. Choi and April are on their own when a pregnant woman delivers. Dr. Rhodes finds himself operating on a patient that is of great importance to Det. Halstead.

April finds herself in a dangerous situation and Natalie gets an update on Will. Dr. Rhodes gears up for a gala honoring his hybrid O.R. and tries to convince Dr. Bekker to join him.

Halstead takes heat for making an unauthorized move to treat his pregnant patient. Choi becomes personally invested when treating a homeless veteran. Rhodes and Bekker deal with a patient who desperately needs a liver transplant.

Halstead hides the theft of his gun from a suspicious Manning. Tensions are still high between Connor and Bekker, who take a risk operating on an HIV-positive patient. Hank breaks down when he sees a patient from his past.

The team deals with the aftermath of a school bus crash. Dr. Charles worries Dr. Halstead is putting his medical license in jeopardy. Maggie helps a friend in need.

Two brothers in critical condition are rushed into the hospital by their parents, leaving Dr. Choi, April and Dr. Charles to tend to their care and left to piece together what actually transpired. Dr. Manning becomes suspicious of a new mother entering the E.D. Dr. Halstead’s tireless activities at the safe injection site start to take a toll on his work.

The staff adjusts to the new normal of the pandemic. Dr. Choi, Dr. Lanik and April fight on the front lines. Dr. Halstead and Hannah face a troubling reality. Dr. Charles tries to clear the air with his daughter following recent developments.

Goodwin announces a new ED Chief and the choice doesn't make everyone happy. Dr. Manning takes a stand for her patient and finds herself dealing with the repercussions. Dr. Charles tends to family affairs.

Dr. Charles and April team up to take on a mysterious patient in the ED. Dr. Halstead is forced to make a life-or-death decision for one of his trial patients. Dr. Marcel is confronted by his past when a former acquaintance is brought into the ED.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Will runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Ethan struggling to get through the day.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Charles and his daughter. Maggie must make a choice that will change Auggie's life.

As Maggie deals with her own trauma, she steps in to help a mother in need. Dean continues to stir the pot with more than one doctor. A patient comes to Med needing immediate treatment, but doesn't want it from them.

Crockett deals with a patient who ends up having more in common with him than he thinks. Will and Ethan clash over a pregnant patient with an irregular heartbeat.

Ethan teams up with an unexpected person to treat a famous tennis player who is afraid his career might be over. Goodwin's new protocols cause a stir.

Dean and Ethan respond to a scene that brings back some bad memories. When Carol's condition worsens, Natalie is willing to do whatever it takes to get her mom feeling better.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.

Third-year med students begin their rotation in the ED and Maggie keeps a careful eye on one of them. Natalie, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.

Crockett worries he made a surgical error when a recent transplant patient comes in with complications. Carol is once again in distress. Will and Natalie must take action to right their wrong.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.

Will Halstead returns to Med to help Goodwin with a secret investigation. Archer and Charles deal with twins who insist on being identical inside and out. Stevie and Dylan treat a young patient with sickle cell anemia.

Stevie’s personal and professional worlds collide when her mother becomes her patient. Dylan’s history with the father of a patient interferes with his perception of a case. Crockett's allegiances are challenged when his patient's liver is a potential match for one of Dr. Blake's patients.

Crockett helps Dr. Blake replace a patient’s liver. Vanessa tries to prove herself. Will continues to pursue the truth about Cooper. Ethan gets closer to returning to life in the E.D.

Dylan's loyalty to Med and the police department is challenged when an old family friend and veteran cop exhibits concerning behavior. The annual random drug testing puts a doctor’s career in jeopardy. Ethan tries a risky old-school method on a patient. Will helps Stevie search for her mother.

The outcome of Will's investigation weighs heavily on his mind as he works with Dylan to save a 4-month-old patient. Stevie and Vanessa both struggle to keep their secrets. Crockett and Blake work with Abrams to save a patient in need of a liver transplant.

In the aftermath of the Vas-COM scandal, Goodwin clashes with the hospital’s new compliance officer. Crockett and Blake try to save a patient who has a son with severe autism. A patient’s son lies to his father about his diagnosis.

Crockett and Blake clash with Randall when a famous alcoholic football player needs a liver transplant. Dylan is reluctantly reunited with old friends when their son breaks his arm. Stevie and Charles work together when a patient falls ill after back-alley plastic surgery.

Scott and Archer diagnose a pregnant woman with a serious infection. Maggie receives shocking news. Halstead and Charles question an elderly patient’s Alzheimer’s diagnosis. In an effort to help a patient, Marcel takes a risk.

Goodwin assigns Med’s new compliance officer to a patient with a long-hauler COVID condition. Maggie helps Halstead treat a patient who's been in an iron lung for 60 years.

Scott suspects his patient may be a drug dealer. Halstead must decide how to spend his whistleblower settlement. Charles and Taylor help a patient who believes she's infested with parasites. Marcel and Blake are paired with an arrogant surgeon.

Halstead helps a patient with long-haul COVID-19 symptoms. Taylor reflects on her dating life when she learns that a patient's daughter is having an arranged marriage.

Archer and Asher clash over a patient with close ties to Goodwin. After a patient is shot during a home invasion, Scott and Marcel help with the investigation. Maggie and Halstead work to protect a patient who is in the country illegally.

Halstead and Asher work to save a surrogate's baby. Charles cares for a patient on a hunger strike. Choi and Archer help a patient with ties to Choi's late father. Scott and Maggie are stumped by a drunk patient who claims to be sober.

Scott helps the daughter of a mob boss. A grandmother comes to Med desperate to save her grandson. Choi struggles with some shocking news about his father.

In the aftermath of Halstead's apartment fire, Marcel, Choi and Archer work together to try to save the survivors. Charles and Med's new fellow, Cuevas, help a paranoid patient.

Supply chain disruptions dramatically impact Med, causing Marcel to clash with other doctors. Maggie reveals something to Ben. Choi and Archer help a patient with ALS.

Charles and Cuevas clash over the treatment of a paranoid patient. Choi treats a pregnant patient from Asher's past. Marcel and Taylor help a man who needs a risky neurosurgery.

When a subway train goes off the tracks, Marcel volunteers to help the victims. Taylor and Halstead must decide if they’re willing to risk their jobs to save a patient. Asher and Archer clash over a pregnant patient.

The effects of the supply chain shortages continue to impact the ED when Taylor's drug dealer reappears. One of the victims of the recent train crash needs a transplant.

Marcel adjusts to his newfound fame when he helps Halstead treat a local restaurant owner. Choi, Charles and Goodwin aid a new mother worried about hurting her baby. Maggie and Taylor clash with a patient eager to get back to work.

Med runs out of scrubs, forcing the staff to improvise. The life of Archer’s son is in danger. Marcel and Charles help a kidney transplant patient experiencing psychosis. Asher and Halstead grow closer.

Halstead and Marcel facilitate a trans-organ exchange. Asher and Cuevas help a sexual assault survivor. Choi and Archer treat a patient whose case could expose a fraudulent doctor.

Halstead relies on Marcel and Med's newly donated OR 2.0 to save his patient. Charles helps an elderly, confused patient who's mourning the loss of his high school sweetheart. As their wedding day approaches, Choi and April run into some roadblocks.

Charles and Cuevas help an elderly patient and her developmentally disabled grandson. Halstead treats a swimmer with a heart condition. Marcel considers using the OR 2.0 for surgery.

Marcel and Charles treat Lieu's gym buddy. Maggie and Halstead help a robbery-homicide suspect. Asher and Archer use Med's new opiate abuse AI program.

Goodwin, Maggie and Marcel help victims of a hit-and-run accident. Halstead struggles to diagnose a patient with seizures. Asher and Archer clash with Jack Dayton.

A brutal storm rocks Chicago. Halstead encourages Dr. Grace Song to go against her own findings for the benefit of their patient. Asher rushes to the hospital to help Archer's pregnant patient. Maggie's concern for Ben consumes her.

Goodwin and Charles clash as negotiations drag on between the administration and the custodial workers' union. Asher fights to keep a mother and her newborn baby together.

The hospital is in disarray when the janitors go on strike. Marcel treats a young girl injured on her family's farm. Charles and Cuevas' schizophrenic patient returns to Med.

Halstead and Cuevas struggle to diagnose a patient with a rare disorder. CFD and Med staff work to free a paranoid father trapped in the MRI suite. Tanaka-Reed gets an ego check.

A documentary crew visits Med to film Marcel and Abrams' groundbreaking surgery. Archer refuses to ask for help for his kidney issues despite the staff's unrelenting kindness.

Dr. Song launches her pilot program, giving the E.D. a technological facelift. Archer clashes with Charles on a patient faking paralysis. Archer helps a pregnant mother with a heart condition.

The fate of the hospital rests on the vote of an incapacitated board member. Archer helps a mother with a rare stem cell disease while Asher treats the woman's pregnant daughter. Charles encounters a schizophrenic patient with a hearing impairment.

Maggie clashes with Charles over a distrustful patient. Marcel and Halstead fight against Med's new policies. Asher and Archer pull surprising things out of their unsuspecting patients.

Shocking information threatens Jack Dayton's surgery and the future of OR 2.0. Archer goes rogue to save a patient in need. Maggie questions her future at Med.

When the E.D. is flooded with patients from a crash, the entire team is pulled in to help. Charles can't shake the feeling that he knows the new E.D. attending. Archer has second thoughts on the eve of his kidney transplant.

A woman from Archer's past returns and threatens his transplant surgery. Marcel clashes with Med's new eager first-year resident. Charles works to repair his relationship with Ripley.