The hospital is forced to evacuate when a toxic chemical is brought into the E.D., leaving patients and the staff in grave danger. Stuck in an elevator, Dr. Charles and Dr. Manning are forced to take drastic measures with a pregnant woman. Goodwin is tasked with making difficult choices and Dr. Rhodes discovers a secret that Dr. Bekker has been holding from him.

Dr. Halstead rushes to rescue Dr. Manning after she is involved in a Medevac helicopter crash. The personal drama between Dr. Rhodes and Dr. Bekker boils over. Dr. Charles and Dr. Choi work to help a patient come to terms with their addiction. April helps Elsa deal with the loss of her first patient.