Brian's loyalty to the FBI is tested when Sands, Senator Edward Morra's representative, demands he steals the FBI's secret files on NZT. Also, Agent Harris is emotionally conflicted when she learns what her estranged father left her following his death.

When Brian begins to experience the side effects of NZT again, Senator Morra demands he betrays Rebecca in exchange for another inoculation. Also, Brian secretly looks for an alternate cure for himself while he works with Rebecca outside FBI parameters to find the creators of NZT.

Brian offers to use NZT to capture the FBI's "Ten Most Wanted" criminals in two weeks, in exchange for Naz giving him his own personal work "headquarters" at the agency. Also, the secretive nature of Brian's new life working for the Bureau creates a rift between him and his father.

Following a stunning betrayal to their team, Brian and the FBI race to stop an NZT-enabled Sands and his associates from orchestrating an international incident. Also, Brian experiences devastating side effects when his NZT immunity starts to wear off.