When Kara’s attempts to help National City don't go according to plan, she must put aside the doubts that she -- and the city's media -- has about her abilities in order to capture an escapee from the Kryptonian prison, Fort Rozz. Also, Cat pressures James to use his connection to Superman to get her an interview with Supergirl.

Supergirl’s powers are tested when Reactron, one of Superman’s formidable enemies, arrives in National City and targets the young hero. Also, Cat plans to run an exposé on Supergirl.

Kara's Thanksgiving may be ruined when she suspects her foster mother, Dr. Danvers, who is coming to town, disapproves of her new role as a superhero. Also, when an accident transforms a volatile CatCo employee into the villainous Livewire, she targets Cat and Supergirl.

Kara’s two identities are stretched thin when Supergirl must protect National City from a series of bombings and Kara is tasked with babysitting Cat’s son, Carter. Also, James is conflicted when his ex-girlfriend Lucy Lane seeks to rekindle their relationship.