Kara joins Nia on a trip to Nia's hometown to visit her family during the town's annual Harvest Festival. While home, Nia's mother encourages her daughter to embrace her destiny. Meanwhile, Alex deals with a street drug that is turning people violent and giving them temporary superpowers.

In the wake of Lex Luthor's return, the show flashes back to what he's been doing for the last two years and how his secret machinations and plans have affected Supergirl and Lena.

Lex Luthor descends upon Washington, DC and summons Lena and Lillian Luthor to the White House. Supergirl realizes she has one last chance to stop Lex and turns to the power of the press to help her.