Malik and Zoe don't see eye to eye when it comes to using a revolutionary procedure involving spider silk to save a boy's crushed legs versus the safer route of amputation. Elsewhere, James, Walter and Talaikha care for a young woman in desperate need of a liver transplant who, to their surprise, is reluctant to accept a donation from her estranged father.

Angie tries to target her mother’s illness using radical nanobot technology, but she looks to Scott for help when her mother prefers using traditional methods. Also, when a graffiti artist with a clotting disorder falls from a bridge, Walter, Malik and Zoe attempt to use suspended animation to stop his internal bleeding.