Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, “The Ghost”, a notorious criminal whose work killed his mentor, and track him down before he strikes again.

MacGyver is tasked to go undercover as an inmate in a maximum security prison to break out El Noche, a notorious drug kingpin, using only batteries and salt, and track him to his cartel's secret location and dismantle it.

Mac and the team have no time to reminisce while visiting Mac’s and Bozer’s hometown when they immediately start searching for a kidnapped prodigy from Mac’s old middle school, Valerie.

When Matty’s goddaughter and her boyfriend are killed in a San Francisco park, Mac and the team investigate the crime and start to suspect that the 1970s Zodiac Killer has returned.

MacGyver uses a heater and hot sauce to help a key presidential candidate in Ecuador receive a heart transplant he desperately needs after a rebel group tries to sabotage delivery of the organ.

When 32 college students are stranded on a research ship in the Arctic Ocean with no heat and erupting fires, Mac develops an emotional connection to the group leader, via video chat, as he relays how to stay alive as they await a rescue ship. Also, Jack kidnaps Elwood to find out what scam he’s up to next, and Bozer’s feelings toward Leanna grow stronger.

Mac and Jack attempt to rescue a billionaire’s son after he is kidnapped by a former Navy SEAL who uses an EMP weapon to cut off power and communication lines to the Shanghai skyscraper where the boy lives.

When Jack receives an emergency distress signal from one of his old Delta buddies who is falsely accused of terrorism in a foreign country, MacGyver and Jack quickly recruit the rest of Jack’s old Delta team and stage an unsanctioned rescue op.

MacGyver and the team set off on a dangerous capture operation after an Irish military intelligence officer approaches them claiming to know the whereabouts of “The Ghost,” a lethal bomb maker whom Mac has been hunting for years.

The Phoenix teams up with a woman who’s a soccer mom by day but a master thief by night to catch one of her contacts, an underworld criminal, who has hired her to steal a dirty bomb.