Six months after leaving Chicago, Father Tomas and Marcus Keane's travels lead them to a troubled young woman in rural Montana. On a secluded private island off the coast of Seattle, Andy Kim runs a group home for at-risk foster children, whose lives are disrupted when the state sends a social worker.

Marcus and Tomas travel to Seattle where they find a young girl targeted by a force of pure evil. Meanwhile, Father Bennett tracks down a rogue church operative named Mouse who is waging a one-woman crusade against the demonic conspiracy.

Andy's foster home receives a surprising new addition as he confronts the strange incidents occurring on the island. Meanwhile, Bennett's uneasy partnership with the enigmatic Mouse takes a dark turn.

As Tomas and Marcus continue to investigate the strange incidents at the foster home, the demon finally makes its presence known. Meanwhile, Andy and Rose take the children on an overnight camping trip, setting them on a collision course with the supernatural presence on the island.

A visit to the foster home carries deadly consequences, as Marcus and Father Tomas attempt to draw the demon out of hiding. Rose finds herself the target of the demon's wrath. And no one suspects that a new danger may be lurking in the woods, waiting for its moment to strike. Meanwhile, Father Bennett and Mouse take the fight directly to the conspiracy as they attempt to hunt down an old adversary.

As the exorcism begins, the fate of the foster home hangs in the balance. This is an adversary unlike anything Marcus and Tomas have ever faced, and in order to save this family, the two of them must journey into the mouth of madness itself.

As Father Bennett and Mouse head west to rendezvous with Marcus and Tomas, new details about Mouse's tragic past comes to light. With time running out to finish the exorcism, one of the foster children is faced with a difficult choice. But the demon has other plans.

As the exorcism reaches a critical juncture, Tomas engages the demon in a desperate battle to save Andy's soul. Meanwhile, Marcus and Rose attempt to get the foster children off the island, but the demon has other plans. As the storm of the century descends upon the island, salvation may come from an unlikely source.

Everything has led to this moment. As one priest fights for his life in the hospital, another is forced to confront the ghosts of his past. With time running out to save Andy's life, one of the exorcists must make the ultimate sacrifice.