When he realizes that his first choice for Vice President faces an uphill fight for nomination, Jed nominates a congressman that none of the staff can get excited about; Josh is less than thrilled with his new intern.

Josh fails to sway an unruly congressman who insists on voting against the administration on the vice presidential confirmation, but Ryan reaches out to get him to change his mind; Leo fears that the potential defection of a prominent North Korean pianist will jeopardize secret nuclear disarmament talks; Will and Toby are humiliated when an early draft of a speech outlining their struggle to laud Bob Russell's confirmation is erroneously substituted for the final version; Donna's aunt and uncle from Wisconsin pay a visit, testing Josh's ability to refrain from bad cheesehead jokes during their tour of the White House; the staff struggles over how to language the state of the economy; fearing that the administration is drifting off-course, Toby wants to hand over more responsibilities to Will in order to focus on getting back to their core message.

Will Bailey receives an offer to become Vice President Russell's top aide. Amy Gardner does some skillful lobbying for domestic violence prevention which gets the wrath of Bartlet. A conservative democratic senator switches parties.

The fallout on the Hill from Carrick's switch to the Republican party exiles Josh deep into a White House doghouse, so C.J. gives Donna some tips on how she can support him; Jed gets a harsh reality check from C.J. when he lingers too long in a small Oklahoma town devastated by a deadly tornado; in Jed's absence, Leo juggles an impending war between Albania and Greece, a visit from the German chancellor, a tussle over tax cuts, and an over-reaching Secretary of Defense; Josh and Toby are less than thrilled when Leo brings Angela on board to assume some of Josh's responsibilities.

As Chief Justice Ashland's health problems continue to mount, Joe Quincy, Ashland's former clerk, is pressed into service to persuade him to retire; as C.J. prepares Zoey for a sit-down interview about her kidnapping, Abbey reveals that her relationship with her husband is still strained; Jed refuses to be held hostage by the Republican in the budget negotiations.

Jed's decision not to be held hostage by Haffley shuts down the federal government; unable to get through to Jed and fearing the worst, Leo calls in the reinforcements, and Abbey returns to Washington to deliver a message and provide her husband with a little perspective; after being benched from the staff meetings, Josh gets put back in the game by Jed and sets the stage for victory; disregarding the advice of more seasoned colleagues, Haffley makes a major misstep and loses his advantage over the White House; Jed and Haffley meet and reach an accord on the budget.

An unlikely party comes to the aid of the administration as it seeks to discover the party responsible for nuclear testing in the Indian Ocean; Will is unhappy, but his boss doesn't seem to mind, when a request to beef up the Vice President's issue profile results in Toby's handing him boring, low-level minutae; Josh dismisses a NASA proposal for a manned Mars mission until an agency staffer shows him the error of his ways; a conservative talk show host makes a pathetic attempt to bait C.J. into appearing on his show.

When a conservative Republican Congresswoman targets Ellie's research project in an effort to discredit Jed, Toby discovers that the source of the leak is uncomfortably close to home, and Will realizes that they've all greatly underestimated his boss; Josh investigates the wisdom of a recess appointment as he tries to convince an old friend to be patient with the Sixth Circuit judicial nomination process and keep his hat in the ring; C.J. completely misreads Ben's intentions; Donna tracks down an AWOL Ryan; an opening is created on the Supreme Court; in an effort to redefine Abbey's image with the press, C.J. sets her up to do a public service announcement with the Muppets, which inspires Ellie to stand up before the press in defense of scientific research unhampered by politics.

Jed weighs his options for responding to the bombing as Israeli and Palestinian forces face off against each other; Josh has an interesting reaction when Colin arrives at the hospital to visit Donna; Kate and Leo clash over the advice she's giving Jed; Josh assumes a diplomatic role when the Palestinians approach him to initiate settlement discussions; Toby and Charlie prepare a reluctant Jed for throwing out the first ball at Camden Yards; Donna's life is threatened when she develops a pulmonary embolism; Jed reflects on the days prior to his first inauguration.

Hours before the CAFE standards amendment is defeated, Josh succumbs to the lure of test driving a monster SUV while shopping for a Prius and gets into a fender-bender that proves embarrassing to the administration, so he's saddled with heading up a task force on alternative energy sources; after hosting a surprise graduation party for Charlie, Zoey agrees to his taking her out to a thank-you dinner; Annabeth educates Toby on the art of "charm and disarm" in handling the press; Charlie is offered an attractive way out of his employment dilemma; Kate extents a hand of friendship and support to Donna; C.J. gets some crucial insight from Leo on keeping Jed healthy; Margaret's plan to redecorate Leo's former office meets with resistance from her new boss.

Hoynes throws his hat in the presidential ring, and asks Josh to join his campaign; Jed's health begins to deteriorate; Toby and Kate head the protocol negotiations with the Chinese over the arrangements for the upcoming summit, which is jeopardized when Jed mistakenly accepts a Taiwanese flag at the National Prayer Breakfast; Bernard takes his new position as head of the Gifts Unit to heart as he gives Charlie a hard time about retrieving the flag so that it can be returned; Josh has his hands full with a pro-Taiwanese senator holding a hard line on recognizing their independence; Bob Russell crashes an Oval Office photo op with the governor of Pennsylvania, who's also another potential presidential candidate.

Penn and Teller roll a lesson about the First Amendment into their entertainment at Zoey's White House birthday party, setting off a media frenzy and public relations nightmare; Baker drops out of the race, leaving the field free for Russell, who asks Josh to run his campaign; Jed takes a hard line on making significant gains on substantive issues in his last China summit; Vinick turns down Jed's offer of the U.N. ambassadorship to run for president; a fully ambulatory Donna has difficulty scheduling a meeting with Josh; Jed has an MS relapse which leaves him partially paralyzed and in a wheelchair.

As acting chief of staff, Josh calls Leo in for backup when the news about Jed's health hits; the staff follows the progress of an asteroid headed for earth; Jed struggles with his relapse as C.J., Kate, and Toby handle the repercussions of his illness on the progress of the China summit; Josh is outraged when Will uses Jed's paralysis as a political opportunity for Russell; Donna resorts to extreme measures when Josh avoids her repeated attempts to sit down for a personal discussion; after receiving some wise advice from Leo about the future, Josh makes a decision about the man he'll support in the upcoming presidential election.

A senator attaches a rider to the federal budget bill that would ban gay marriage, almost daring the President to veto it, as the physical infirmities of Bartlet's MS become more pronounced. The Internet is rampant with a story that questions CJ's sexual orientation, and it is only fueled further when CJ refuses to dignify the allegations by putting out a statement. Donna joins the Vice President's senior staff, and heads for New Hampshire to start up Russell's presidential campaign there. And Santos decides that he will run for president after all, but only if Josh will leave the White House to manage his campaign.

The presidential candidates journey to Iowa, where democrats Russell and Santos, and republican Vinick, are all told by their handlers that when they appear before before the corn growers association they must support subsidies for the use of corn-derived ethanol as fuel, regardless of their true feelings.

It's five days before the New Hampshire primary, and Josh is desperately trying to find a "silver bullet" that will get his candidate into the local debate between the two front-runners, Vice President Russell and former Vice President Hoynes. Then, Josh and Santos's disagreements over how to run the campaign come to a head when Santos hires Josh's ex-girlfriend Amy Gardner to help him prepare for the debate he may never be in. And Donna has a memorable encounter with a chicken.

Santos is campaigning in California during the last few days before the all-important "Super Tuesday" primary elections, but he is out of money and he trails both Russell and Hoynes in the polls. When even "La Palabra", a Latino voters group, is all set to endorse Hoynes instead of Santos, Josh urges Santos to take a stand on the new bill that denies driver's licenses to illegal immigrants. Meanwhile, Donna tries to figure out why Hoynes suddenly isn't campaigning in California, and advances her position in the Russell campaign by becoming the Vice President's official spokesperson.

Senator Vinick, now the Republican Presidential nominee, receives advice from former Bartlet political consultant Bruno Gianelli on how to win all 50 states in the general election, and more specifically in the near term how to present his religious views to the public and pick a running mate. Meanwhile, Bartlet wrestles with getting a minimum wage hike passed by attaching it to a bill necessary to raise the debt ceiling, and with how to unify his party in the face of a three-way race for the Democratic nomination.

Faced with a Democratic party in disarray in the face of the strongest Republican challenger they have ever had, Bartlet asks Leo to take charge of the potentially chaotic Democratic National Convention, while Santos considers a party-unifying vice-presidential offer from front-runner Russell. Meanwhile, the International Space Station is leaking oxygen and a rescue of the three astronauts will be difficult, and Bartlet catches Charlie leaving Zoey's bedroom after a nighttime visit.

At the Democratic National Convention, Russell, Santos and Baker jockey for the 2162 votes that will give one of them the nomination for President, and the opportunity to lose to the apparently unstoppable Vinick in November. Meanwhile, the President must make a decision before it's too late on whether to deploy a secret rescue mission to the space station, and the FBI is asked to determine who leaked the existence of the military shuttle to the press.

Former series regulars, including Marlee Matlin, Mary-Louise Parker, Tim Matheson, Anna Deavere Smith and Gary Cole, make guest appearances as Bartlet, Santos and their staff members attend a funeral for one of their own. Also, Josh cautions Santos about getting involved in the vote for Speaker of the House.