The divorce between Gabrielle and Carlos reaches new levels of bitterness. Susan is determined to jog Mike's memory, and realizes Edie has been posing as his girlfriend since he woke up. Tom decides that his dream is to open a pizza parlor, and Lynette is not delighted. Bree tries to break up Danielle and her history teacher, who's been having an affair with her. Meanwhile, Mike's phone number is discovered on a dead woman's body.

Ian proposes to Susan. The Scavo pizzeria prepares for its grand opening. Mike visits a hypnotherapist in hopes of remembering Monique. Gabrielle's romantically interested in a lawyer, but he's working for Zach who wants her for himself. Bree is hospitalized after a fall, after being tricked to climb on a ladder to retrieve Monique's teeth.

Lynette's sisters Lydia and Lucy come to visit. While having dinner with Susan and Mike, Bree and Orson realize they share different views on whether their newborn baby should be circumcised. On a boat, Victor confronts Gaby about her affair with Carlos and she throws him into the ocean. Later, Bree informs Susan that she thinks Mike is addicted to drugs.

Adele Delfino, Susan's mother-in-law, arrives for a visit. Carlos and Gabrielle find out their tenant, Elli, has a dark secret. A full scale war erupts between Bree and Edie.

For Gaby and Carlos, injuries sustained in the fire lead to a fortunate discovery. But for most, the consequences are less forgiving. Lynette and Tom vow to protect son Porter at any cost. Susan must learn to let go of the man she loves. Orson's attempt at a good night's sleep puts Bree in a most precarious, though amusing, position on the day of her big cooking demonstration.

Bree treats herself to a new car; Susan wants to send M.J. to the best school even though she and Mike can't afford it; Gaby tries to get back into shape; Lee wonders if he should tell Tom and Lynette some disturbing facts about Dave.

Carlos finds Lynette in a precarious position, which she chooses to hide from Tom, and Gabrielle hastily covers for Tom's coy behavior. Orson tries to hide the truth about his wounds from Bree, while Katherine confesses to Mike, which leads to a surprising realization. In the meantime, Susan confides her dark secret in Dave.

Losing Mike takes its toll on Katherine. As Katherine unravels, Bree comes to her aid; Gaby grows weary of John’s intentions towards Ana with twins on the way, Lynette calls upon her family to step up around the house Susan learns Julie has been harboring some secrets and Angie throws a party for son, Danny.

Former exotic dancer Robin will have a profound effect on Susan's friends with three teenage boys at home, Lynette will keep a watchful eye; Bree picks up a few tricks to engage Orson; Gaby looks for help with troublesome niece Ana; and Katherine will find a friendly companion.

Angie comes face to face with her ex, Patrick Logan, after years on the run. Meanwhile, Gaby and Susan plan an elaborate scheme against their husbands, Lynette sees a darker side of Eddie, and Bree meets a woman who knows Sam all too well.

Paul finds out that Beth is Felicia Tilman's daughter while a therapist asks Carlos and Gabrielle to erase Grace from their lives. Susan finds out she needs to go to the hospital every 48 hours and Renee finally tells the secret between her and Tom to Lynette. Orson returns and Bree gets torn apart with her feelings between Orson and Keith and detectives try to find the person responsible for shooting Paul Young.

Paul tries to stand between Susan and her kidney transplant; Felicia is released from prison and swears revenge against Paul; Gabrielle is furious about a neighborhood party planned by Renee; Tom is caught between working with Carlos and a job opportunity; Andrew's drinking concerns Bree.

With Gaby and the girls temporarily staying at Bree's house, Bree must lay down the law and demand discipline before Juanita and Celia destroy her home. Meanwhile Tom hires Lynette and Renee to redecorate his office - but Lynette has her own ideas of what she thinks Tom needs as opposed to wants; and while continuing to help nurse Paul back to health, Susan discovers that Felicia has been released from prison and is back on Wisteria Lane.

Lee has a problem with Jenny; Susan and Carlos attempt to find the people responsible for tagging the wall with graffiti; Lynette grows suspicious of Lydia and her fiancé.

Gabrielle, thinking the worst, goes on a frenzied search for Carlos after he unexpectedly checks out of rehab. Meanwhile, a desolate Bree goes on a drinking binge and finds herself in a desperate situation.

In the penultimate episode leading into the two-hour finale of this landmark series, as her trial nears, Bree begins to fall for her attorney, Trip; Susan becomes concerned when Julie doubts Porter's commitment to be a hands-on father to their unborn baby; as Tom gets closer to being transferred to India for his job - thanks to Lynette - she begins to have second thoughts and tries to convince his boss to rescind the move; and the ladies are shocked about Gaby's nonchalant attitude as Bree continues to stand trial and take the fall for Carlos in the murder of Alejandro.