Rachael Leigh Cook smashes more than eggs in her latest This Is Your Brain on Drugs public service announcement. Optimus Prime, leader of the Autobots, falls prey to prostate cancer. The outcome is never in doubt during "World's Most One-Sided Fistfights Caught on Film." Outtakes from The Dukes of Hazzard, The X-Files, Battlestar Galactica and more come to light in "Bloopers."

The animals Noah left behind try to survive the flood in their very own ark. Enjoy instant nostalgia with "That '00s Show." Mrs. McNally's third-graders produce an animated abomination in "The Best Cowboy." The world's most famous cars, from KITT to the General Lee and even Mario karts, race against each other in "3 Fast 3 Furious."