A salaryman named Sanematsu takes care of his six siblings, the Matsuno brothers become girls and argue, and a fight between Choromatsu and Osomatsu occurs.

Wanting to become the main protagonist of the franchise again, Iyami holds a bizarre kart race to determine who the protagonist of Osomatsu-san will be.

Iyami goes to sextuplets for help after falling on hard times and Hatabou searches for a friend.

Already angered over the siblings gambling instead of paying off their oden tab, Chibita vows revenge on them after they pluck out his one-and-only hair. That night, Chibita begins taking out the siblings on by one, shaving all of their hair and stuffing oden in their faces.

Jyushimatsu befriends a young boy named Eitarou but gets called in by Eitarou's mother when he starts imitating him. Contrary to Jyushimatsu's fears, however, she asks him to teach Eitarou jokes so he can make friends at school. Later, Dayon steals Dekapan's underwear, forcing him to give chase all over the city while butt naked.

A group of aliens pursue the legendary space pirate, Shazarr. Displeased with Chibita's oden, Matsuzou serves up his own brand of oden, only for noone to show up. Later, the sextuplets become enamored by their new neighbor, Kinko Inuyama, prompting jealousy from Totoko when they go on a date with Kinko instead of her.

A common scene after a drinking party. Osomatsu and others are sloppy at Ramen Himatsuya. The second. / The life of Dayon, which has been a mystery until now, is revealed! !! And another Dayon appears in front of Dayon! ?? / Recently, Iyami who has lost confidence in doing Osomatsu-san. I consulted with the program producer, but ... / A common scene after a drinking party. Osomatsu and others are sloppy at Ramen Himatsuya. 3rd.