When Cain’s elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation. Conrad and Devon treat a local Congresswoman who withholds information that could prevent her from receiving proper treatment, causing Devon to open up about his grief. In the wake of losing many colleagues to the virus, Bell worries who would be there for him in a moment of crisis and finds himself mining his own past to find his estranged former stepson, elite plastic surgeon Dr. Jake Wong. Meanwhile, Logan Kim finds himself on the chopping block when the doctors are questioned about his actions during the pandemic.

When a tornado touches down in Atlanta with Chastain directly in its path, the entire staff goes into crisis mode. Conrad and Nic work on an injured EMT. Devon and Leela become trapped with a man who has severe head trauma.

In trying to find a way to channel his emotions, Conrad puts all his effort in looking for answers. Raptor has a run-in with the police that ends up taking a surprising turn. Meanwhile, Leela begins noticing problems with a surgeon who has been Bell’s mentor.

Conrad takes Trevor under his wing to care for a patient whose good luck seems to have run out. Leela struggles when given the decision to take full responsibility of her indecisive patient's life and The Raptor continues to try to figure out a care plan for his mother. Meanwhile, both Devon and Kit are stretched far too thin trying to balance everything on their plates

An old friend's heart problems reveal a bigger issue; Billie and Trevor have an emotional reunion.

A young boy comes into the hospital with a rare disease which leaves his bones incredibly fragile; with his clinical trial officially being declared a success, Devon has some huge decisions to make about the future of his career.