Viewers meet the players and learn the concept of the game. The players begin forming coalitions in the hope of making further in the game and learning more about who is the mole. The players all take part in a sky-diving challenge. The players' banking skills are tested in an attempt to earn money for the pot.

A player is "kidnapped" and the rest use all means of transportation to try to save him in order to secure him and money for the pot. The players then split up into three Leaders, three Followers and a Good Eye player for games. One player is busted after an attempt at a sneak-peek at the show crew. Members of the Follower and Leader teams try to navigate a cornfield maze while avoiding guards attempting to hamper their progress.

A bullfighting game confuses the players, but they are still able to earn money for the pot. Some players come face-to-face with their dirty laundry, literally, while others are asked to unpleasant tasks. One player is asked to face all four, but the stakes in this case are higher: more money and an exemption. Fortunately, the negative results are only temporary, at least in some cases.

A sniper game provides a player with a choice between money or an exemption. A losing streak gets the players down, but a school-style challenge gives them an opportunity for big money. Some prove rather easy, while others are too much of a challenge to handle. The game becomes more complicated in a twist in which correct answers lose money for a new group answering the questions. One player claims to have psychic visions about the night's execution, but ends up being executed instead.

The players are divided into "Stupid," "Resourceful" and "Smart" teams for various games. Transportation dilemmas hinder the progress of all of the players. The players then take part in a game that tests how well their loved ones know them. Successful answers earn money for the pot and a chance for the players to see their loved ones, while incorrect answers lead to heartbreak, but only for a short time.

The players compete in a game described as a variation of "capture the flag." The game raises many suspicions as to who could be the mole and causes some finger-pointing. In Spain, the players attempt to decipher Spanish clues to search for books. Alleged verbal abuse causes one player to despair and they are executed.

The players divide into "arty" and "counting" groups and then participate in games in which they herd sheep or create a piece art designed to fool a critic. The sheep-herding group is given a choice of three dogs, with only one trained to herd sheep. They can earn $20,000 for herding them, and an additional $10,000 for counting them. What they don't know is that they've already been told the number of sheep. The players then are asked to challenging tasks, such as facing knife-throwing and fire-walking. The tasks are on a tiered-structure, with varying results worth exemptions and/or cash. The participating players are blindfolded, while another has to convince them to complete their tasks. This player is the only one who knows the truth about their tasks: that they only think they're doing something potentially dangerous.

Now that only three players are left, the remaining players take part in some final games. One mean game forces the players to answer revealing questions about each other, in the hopes of using information earned this way to find each other and earn money for the pot. In the final game, the players are locked in hotel rooms and try to decipher clues working together in order to escape and earn a large chunk of money to the pot. They fail, leading the two actual players to wonder if it was the mole's work.

The final episode reveals the mole and the winner. Montages reveal moley action, previously-unknown alliances and more. Recaps offer a look back at some of the best moments of the first season if the show. The viewers are informed that hidden clues to the mole's identity were placed in episodes throughout the series and these clues are revealed.

The second group of Mole contestants come together and meet each other. They deal with a series of tasks in which they receive money in a group pot. They all receive journals where they are to record their ideas, thoughts, etc. The players must answer a series of questions to keep their belongings from being burned.

The teams complete a series of tasks involving quirky costumes. Two team members decide to lay back and have a beer at a Swiss bar which doesn't go over well with the players. Two players are given the opportunity to earn exemptions by convincing someone to break a rule.

The show performs a journal swap in which each player gets someone else's journal. After a surprise exemption is given out, a third person is executed.

The players have their memory tested in a game in which they try to crack a safe. The players receive a secret telegram that contains a vital, secret and unpicked-up-on clue. A secret game tests the moral integrity of the players and they are then separated into "dumb" and "smart" groups as brainteasers test whether the players in this edition are worthy of the "MENSA" tag the show has earned. One player's rule-breaking actions lead to a fine being levied on the entire group.

Heather, Al, and Myra must escape from jail cells using equipment provided or face missing phone calls home. The others must complete a series of questions then unscramble a final puzzle using the letters of the answered questions, while others players tread water with weights over their necks.

The first challenge divides the players into groups. One must make at least three 12-inch pizzas before 7 o'clock. Another must ride a bike uphill to get 2 bottles of wine for dinner. The players each rank the others from favorite to least favorite.

The least favorite player is given a game changing opportunity.

The players play a game of hide and seek and go bungee jumping for a chance to spend time with a loved one. One gets life changing news, and one is executed.

While one set of players participates in a wine-drinking game, another group is busy trying to assemble a car. Later, the players are led to a small room for a surprise late-night tetherball game. Suspicions abound when strange behavior denies money from the pot and costs another player an exemption, which leads host Anderson Cooper to challenge one player's "moral code."

A shopping spree game features the women shopping for items and the men trying to make a profit off them in a market. Later, the players play a game called Evader. This game offers some valuable money for the pot, but also exemptions to a couple of lucky players.

A special delivery is brought by Kathryn Price, the original Mole. The contestants play a game called High Card, in order to see who has to sleep in Anderson's Funhouse.

The final three players play “Three Questions” to find each other and earn money. In the next game, they race to be the first to find the mole’s dossier by searching for a hidden GPS that will direct them to the final location. After the final quiz, the execution determines the final two.

The players of The Mole II: The Next Betrayal are reunited to take their guesses at who won the game and who is the mole. The answers to burning questions are revealed.

A recap of the first five episodes of season 5, plus never-before-seen footage will air as a one-hour special.