Harley Quinn forsøger at klare sig på egen hånd i Gotham City. Hun får hjælp af Poison Ivy og en broget skare af vragede DC-skikkelser og forsøger at sikre sig en plads blandt den største samling af skurke: Legion of Doom!

Harley er fast besluttet på at blive optaget i Legion of Doom og prøver at blive bemærket ved at blande sig i et af deres kriminelle foretagender med hjælp fra sin slyngveninde, Poison Ivy. Lykkes det hende, eller opnår hun blot ydmygelse?

Realizing she needs a crew to pull off heists that will attract the Legion of Doom’s attention, Harley attempts to recruit Dr. Psycho and Clayface.

In search of a nemesis, Harley goes after Batman, but ends up with an adolescent Robin, making her the laughing stock of the criminal underworld.

When Harley suffers a paralyzing identity crisis, her crew must enter Harley’s mind to free her with the help of Dr. Psycho’s telepathic powers.

When Clayface loses his arm in a heist, it turns out to be not only evidence for Jim Gordon, but also a key witness against Harley and her crew.

Harley recruits her friend and mentor Queen of Fables to help her steal a force field from STAR Labs, to steal a weather-changing machine, so she can impress the Legion of Doom. Meanwhile, Poison Ivy dates Kite Man.

Harley gets an invite to the Legion of Doom’s prospective members party, but Ivy discovers that it’s Lex Luthor they’re really after.

Now a member of the Legion of Doom and The Joker’s equal, Harley finds herself spending time with him. Will she slip into her old ways?

After a falling out with her crew, Harley heads back home to Bensonhurst, where her doting mother waits for her... and her deadbeat dad, who’s more dangerous than anticipated.

Harley must rescue Ivy from the clutches of Scarecrow, who’s trying to harvest her pheromones to make a super toxin that turns plants into sentient monsters.

Harley thinks the Legion of Doom is behind Ivy's capture and the tree monsters currently ravaging Gotham. But it's a trap!

In the season finale, Harley has her final showdown with the Joker, when [spoilers] [spoil] [spoilers]. Will they [spoiler]? Maybe. But you can bet they [spoiler]!

After Gotham is declared no longer part of the United States, the newly formed Injustice League tries to seize control of the city away from Harley.

Harley & Ivy go undercover as college students to take down Riddler, who’s made himself dean of the local university with sinister plans for students.

Harley & Ivy team up with Catwoman to steal a museum artifact that’s been boobytrapped by Dr. Trap. Meanwhile, Dr. Psycho tries to prove himself as a leader.

Harley and crew try to infiltrate Mr. Freeze's lair only to become human lab rats for his experiments to find a cure for his cryogenically frozen wife, Nora.

Bruce Wayne awakens from his coma to Gotham in chaos.

When Harley and Ivy spot a seemingly sane Joker, they debate whether people can change at their core, revisiting a flashback about Harleen Quinzel's first day at Arkham Asylum.

Acting as a judge, Two Face sentences Harley and Ivy to life in Bane's prison. Meanwhile, Jim Gordon and Batgirl vow to take back the GCPD from Two Face.

While Harley & Ivy deal with their post-kiss awkwardness, the President tells Gordon that he must get rid of Harley to put Gotham back on the map.

It's Bachelor/Bachelorette weekend for Ivy and Kite Man.

Alone on Christmas Eve, Harley reconnects with a now-sane Joker and heads to Wayne Tower, where their dinner is interrupted by an escaped Riddler and ParaDemons.

In order to defeat Psycho's army, Harley & Joker need to track down Fables' storybook with the Justice League inside.

Psycho unleashes a mind-controlled Ivy, Clayface, and King Shark on the Justice League who are trying to free Gotham.

Harley crashes Ivy's wedding to stop Gordon and his officers from interrupting the nuptials.

In-character Q&A with Harley Quinn, presented during the DC Fandome August 2020 event.

After fleeing the wedding, Harley and Ivy go on an "Eat Bang Kill" tour that leads them to a secret project Ivy abandoned years ago.

After a heist gone wrong, Harley takes the crew to an escape room to foster camaraderie and sharpen Ivy’s leadership skills.

After receiving a “Best Couple” nomination at the 83rd Annual Villy Awards, Ivy finds herself seated next to her ex’s new girlfriend while Harley goes overboard to ensure their win.

When Frank goes missing, Harley and Ivy follow clues that lead them to a highly unconventional party alongside Gotham’s elite, including Commissioner Gordon – who is hungry for campaign donations.

Harley, Ivy, and Nora travel to New Orleans in search of Swamp Thing, who just might be able to help them find Frank.

When The Joker runs for mayor of Gotham, Two Face attempts to sabotage his campaign.

Harley infiltrates a gala on a mission to confront Frank's captor... only to be entangled in another evil plot.

After Harley receives access to Bruce Wayne's mind, she gets stuck in an endless loop of his most formative memory.

When an inadvertent plant zombie apocalypse breaks out in Gotham, Harley fights to save the city, while Ivy embraces her inner supervillain.

After her terraforming plan goes awry, Ivy is enticed by an offer to take over the Legion of Doom, while Harley questions her path forward.

Harley goes overboard in her attempts to give Ivy the best Valentine’s Day ever. Bane’s efforts to impress an unexpected date go horribly awry. Clayface engages in some self-love.

Harley and Ivy struggle to find their footing in their new respective roles in the Bat Family and the Legion of Doom.

After breaking the Bat Family’s #1 rule, a demoted Harley shadows Alfred, while Ivy finds an unexpected mentor at a networking event.

In Vegas for some much-needed QT, Harley struggles at the Strip's evilest hotel while a desperate lvy tries to secure tickets to Clayface's show.

Lex Luthor keeps Ivy on a short leash at a conference on the moon, while the Bat Family rents out Wayne Manor after Talia slashes company finances.

When Batgirl goes missing, Harley goes on an adventure with her roommate, while a spotlight-shy Ivy connects with a PR team after her Malcon success.

Harley investigates the sudden death of a hero, while Ivy tries to take down the Jons and Joker announces a career change.

Harley’s desire to spend more time with Ivy sends them to a post-apocalyptic future. Batgirl seeks out a killer. Joker gets caught in a lie.

While Lex lays siege to the LOD after coming up short with his Ozone Machine, Bane travels to Italy to fix a pasta-maker… and win Nora’s affection.

In a bid to stop Lex, Ivy competes in a celebrity golf tournament. Meanwhile, Harley learns a dark truth about herself... from herself.

Ivy crashes a birthday party on the moon. Harley contemplates how to best avenge her friend.