Alexas plan att dölja cancern från sina klasskompisar och börja high school som alla andra fungerar perfekt – tills hon börjar tappa håret.

Tjejerna döljer Alexas sjukdom med en färgglad lösning, men Dave har svårt att vänja sig vid dotterns nya utseende.

Det går rykten på skolan om att någon i klassen har cancer. Katie provspelar för basketlaget och Lori börjar arbeta hemifrån.

Alexa gör allt hon kan för att bevisa att det inte går att straffa henne. Jennifer överraskar Jack med camping i trädgården, men har svårt att få honom att koppla av.

Katie får huvudrollen i skolpjäsen, men börjar ifrågasätta om hon verkligen förtjänade den. Jennifer ber Lucas om hjälp med barnpassning.

Nu när alla känner till Alexas hemlighet har de blivit outhärdligt trevliga – till och med Gwenny. Jennifer och Jack bjuder in sig själva för att titta på baseboll.

Att kyssa eller att inte kyssa? Katies nya teaterintresse gör att Alexa känner sig lite utanför. Jennifer anklagar Lori för att ha stulit uppmärksamheten från henne.

Alexa får så fint stöd på sjukhuset att Katie inte riktigt vet vilken roll hon själv ska spela. Lori får utlopp för sin oro genom att baka.

Läkarna beordrar Alexa att stanna hemma, men hon kan fortsätta att gå i skolan – via sin iPad. Jennifer gör allt för att övertyga Jack att hon har ett coolt jobb.

Alexa propsar på att laga thanksgivingmiddag, men Lori har svårt att släppa taget. Katie försöker desperat att lära känna sin pappa på ett djupare plan.

Dave ser fram emot att visa Lucas sin gamla skola, och med familjen bortrest får Alexa tillfälle att bryta mot alla regler.

Lucas längtar efter lite grabbhäng nu när Dylan och Alexa umgås. Dave misstänker att något skumt är i görningen … och han är på rätt spår.

Alexas första high school-dans närmar sig, men ett farligt influensautbrott hotar att förstöra det roliga.

Sophomore year is off to a good start for the girls until Katie twists her ankle. That gives Alexa something else to focus on while waiting to hear from her doctor.

Katie is thrilled when chosen to study acting in London. But the $2,000 tuition is way out of her financial range. So she takes on a series of odd jobs trying to come up with the money to send her to the UK.

Katie applies for a job at the coffee shop without telling her mom. When Lucas and Gwenny go out on a date, the girls are determined to sabotage it.

Alexa gets the doctor's OK to play basketball but struggles on the court. A heart-to-heart with another young cancer patient reminds her of how far she has come.

When Alexa and Dylan get into a fight right before the big Halloween party, Katie's sure she can fix it. But what if they're not meant to be together?

Alexa claims she's fine -- so the girls take her shopping for a Sweet 16 dress. Back at the house, a stressed-out Lucas goes to Dave for dating advice.

When Katie needs help prepping for a math midterm, Alexa offers to ask Dylan. Meanwhile, Jennifer still doesn't know her daughter has a job.

Alexa's working overtime to keep Christmas on track. But finding her old hospital bag stirs up memories that throw her off her holiday game.

It's New Year's Eve, and a bold new Katie is finally ready to confess her feelings for Ryan. Cue the fireworks -- and a flaming espresso machine!

An expensive mistake means Katie can't afford to go to London. But she's keeping it a secret so she doesn't ruin Alexa's epic birthday party.

A big fight on the first day of school leaves the girls feeling way out of sync. Lucas starts college, and Lori and Dave toast their 20th anniversary.

Alexa's ready to leave cancer behind her, but it's not that simple. Meanwhile, Katie's trying to balance all the things -- and it's super complicated.

Being there for Spencer brings back memories Alexa would rather forget. Katie looks for leadership opportunities, and Jennifer preps for a date.

Katie and Ryan don't feel the same way about each other anymore, but neither has the heart to say it. Alexa's determined to pass her driver's test.

Alexa's excited to see Dylan again but senses Spencer needs her more. Katie organizes a food drive, and Dave goes overboard on holiday decorating.

Katie aims high to win a community theater competition, putting unnecessary pressure on her friends -- and herself. Lucas reexamines his future.

Alexa struggles to keep her "real" life -- and her life with Spencer -- separate. A horrified Katie's convinced that her mom is dating Gwenny's dad.

Alexa takes Katie miniature golfing to get her mind off the SATs. Lori plays matchmaker when Jennifer hires a handsome handyman.

Alexa eases Katie's anxiety with an epic plan to crush senior year. Jennifer starts her new job, and Jack and Lucas help solve each other's problems.

Alexa's full of advice after getting her driver's license — but she doesn't know everything. Meanwhile at Wired, the new hire is Katie's worst nightmare.

After dating Joe for six months, Jennifer's ready for him to meet her family and friends. It's just dinner ... but Katie's got some concerns.

With college applications looming, an aptitude test reveals Katie's true passion. But pursuing it is scary — and Alexa's "dream job" doesn't feel right.

Alexa agrees to speak at Lori's carnival-themed Stand Up to Cancer fundraiser, where Katie's coffee kiosk brews unexpected jealousy.

College acceptance letters are here. But did Alexa and Katie get into the same school? And why are things suddenly so weird between Alexa and Spencer?

Senior prom is on Saturday, and Katie needs a date. (See also: the courage to tell Alexa something important.) Lori and Joe go overboard at game night.

The girls are finally graduating from high school and getting ready to leave home for college. But will they stay together or go their separate ways?