When five prominent men are killed at a trendy New York City restaurant, the team’s investigation brings them into contact with a lieutenant in Antonio Vargas’ cartel, triggering a long-awaited showdown between Isobel and Vargas.

After a suburban woman is kidnapped from her home, the team looks into trysts on both sides of a seemingly perfect marriage. Also, OA feels pressure from Mona to make changes in his career path.

The team realizes they have a cross-country serial killer on their hands; the case has ties to Isobel's father, Robert, and his hotel, leading to revelations about their fractured relationship.

Maggie returns from medical leave in time to help the team investigate two homicides: a law student on track to attend the FBI Academy and a young man with possible gang ties. Also, an inadvertent revelation from Maggie causes OA to worry that she is rushing back into the job too quickly.