In 1982, two families, the Sanders and the Landrys, are badly shaken when they learn that a mysterious deadly disease called AIDS is threatening the blood system. Each has boys with hemophilia, a genetic condition that means they depend on blood products to live. The medical community struggles to understand the growing epidemic while others deny the urgency.

As the criminal trial falls apart, Ben considers taking matters into his own hands. Peter and Ryan both struggle with illness while forging families of their own. In 2015, both of their lives hang in the balance as the tragedy finally threatens to catch up to them.