The Kingdom of Science is victorious, however it is not over for Senku. Senku must use all of his knowledge to cure Tsukasa who is severly injured.

The battle against Tsukasa's empire is over, and Senku and his team set out to save Tsukasa, who is in cold sleep. To discover the mystery of the petrification phenomenon, the Kingdom of Science finally set out for the New World on the other side of the Earth! Senku and his team begin to build a ship for the voyage. In an attempt to recruit a godly captain with 10 billion navigational skills, they awaken Nanami Ryuusui, the heir to the Nanami Conglomerate and an expert sailor, based on information from Minami, who used to work as a journalist. With his overwhelming greed, Ryuusui creates a currency in the village and enjoys a luxurious life. In exchange for captaining the ship, he proposes he wants the king of all resources, "oil."

While continuing to use the hot air balloon to search for the oil, it's decided that Ishigami Village needs to take up agriculture to prevent future food shortages, as well as to produce preserved food for their upcoming sea voyage.

The Kingdom of Science will need rations to last them through their voyage to the other side of the world. But Senku, being no professional, burns all the bread he attempts to bake.

Senku, brings along a team to look for the Sagara Oil Fields. Meanwhile, Suika and Francois go truffle hunting.

The morse code signal reading "WHY" saturates the airwaves too much for Ukyo to pinpoint a direction, so the Kingdom of Science works on a way to visualize the signal.

Kaseki's efforts to build the science vessel Perseus hit a roadblock when he realizes that it's impossible to get all the parts to fit in practice.

The Perseus crew are on their way to the treasure island, the birthplace of the Hundred Tales, where they hope to locate the treasure box left behind by the Soyuz crew.

The Perseus arrives at the treasure island. A recon squad consisting of Senku, Soyuz, Kohaku, and Gen set off to locate the platinum and make contact with the islanders. Ukyo later discovers something on the seafloor and send Ginro to investigate.

Amaryllis explains how she evaded petrification and how she came to her decision to sneak into the inner palace.

Suika and Ginro work together to rescue the mobile lab from the Perseus. Reunited with Senku and the others, the group works on items to help Kohaku with the selection process.

Amaryllis, Ginro and Kohaku are chosen to join the inner palace. The science team will need a way to communicate with them in secret, and, eventually, a way for them with the science team.

Kohaku has located the treasure left behind by Byakuya and the others, but it's encased in concrete. Senku has to devise a plan to quietly get at the contents inside, so as to not alert the guards.

Kohaku is forced to destroy Ryusui's statue to prove that she isn't a spy.

The team revives Kaseki to work on the drone. Meanwhile, Ginro is called to see the Master.

More of the Kingdom of Science is brought back from petrification, but they are discovered in the cave by Moz.

Moz and the Kingdom of Science form a tenuous, temporary alliance against Ibara. How long it will last is a question they can't afford to concern themselves with just yet.

The Kingdom of Science attacks and tries to execute their plan to steal the petrification device. Moz convinces Kirisame to use the device, but Ryusui's instincts tell him something is off about the situation.

The Kingdom of Science members launch an attack on the islanders aboard the Perseus, but Moz isn't far behind and Senku and the others are forced to retreat inside the vessel. Ibara has them cornered, but Senku unleashes his Joker card.

Yo and the Kingdom of Science capture the petrification device, but Ibara isn't going down without a fight.

Much to Ibara's shock and dismay, Senku devised a plan and managed to escape petrification. Now the two enter into a head-to-head battle for control of the Medusa device.