Several thousand years after a mysterious phenomenon turns all of humanity to stone, the extraordinarily intelligent, science-driven boy, Senku Ishigami, awakens from petrification. Facing a world of stone and the total collapse of civilization, Senku makes up his mind to use science to rebuild the world. Starting with his super strong childhood friend Taiju Oki, who awakened at the same time, they will begin to rebuild civilization from nothing. Depicting two million years of scientific history from the Stone Age to present day, the unprecedented crafting adventure story is about to begin.

The development of glassworks, an important step for making sulfa drugs and for chemistry as a whole, turns out to have a surprising benefit for Suika.

After a successful test of their new cell phone, Senku learns of a mysterious tale about a bee named Speaker who can play the voices of the dead.

Senku continues in trying to advance the Stone World, this time he makes "space food", it is in actuality cup noodles. After Senku finishes his project, Gen has an epiphany and devises a plan to take down Tsukasa's army without violence.

The battle against Tsukasa's empire is over, and Senku and his team set out to save Tsukasa, who is in cold sleep. To discover the mystery of the petrification phenomenon, the Kingdom of Science finally set out for the New World on the other side of the Earth! Senku and his team begin to build a ship for the voyage. In an attempt to recruit a godly captain with 10 billion navigational skills, they awaken Nanami Ryuusui, the heir to the Nanami Conglomerate and an expert sailor, based on information from Minami, who used to work as a journalist. With his overwhelming greed, Ryuusui creates a currency in the village and enjoys a luxurious life. In exchange for captaining the ship, he proposes he wants the king of all resources, "oil."

While continuing to use the hot air balloon to search for the oil, it's decided that Ishigami Village needs to take up agriculture to prevent future food shortages, as well as to produce preserved food for their upcoming sea voyage.

Kaseki's efforts to build the science vessel Perseus hit a roadblock when he realizes that it's impossible to get all the parts to fit in practice.

Kohaku has located the treasure left behind by Byakuya and the others, but it's encased in concrete. Senku has to devise a plan to quietly get at the contents inside, so as to not alert the guards.