When Ludovico asks Leonardo to create an equestrian statue in honor of his father, it stimulates his ambition even more, and the artist strives to exceed the expectations placed on him. While working on the work, Da Vinci places his trust in a person everyone would judge unreliable: Salaì, a resourceful young thief.

Having found Caterina, Leonardo continues his work, but is frustrated by the growing success of a younger artist, Michelangelo Buonarroti. Putting his feelings aside, Leonardo allows himself to be persuaded to accept a new commission.