Set after the events of Continental Drift, Scrat's epic pursuit of his elusive acorn catapults him outside of Earth, where he accidentally sets off a series of cosmic events that transform and threaten the planet. To save themselves from peril, Manny, Sid, Diego, and the rest of the herd leave their home and embark on a quest full of thrills and spills, highs and lows, laughter and adventure while traveling to exotic new lands and locations.

Jack Cooper could be a world-class baseball pitcher if he didn't keep buckling under the pressure. He tries to keep his spirits up after he's traded to a minor league team but loses all hope when he discovers that Ed, one of his teammates, is a chimp. Ed used to be the team mascot, but was promoted to third base when the owners realized he had a talent for baseball. As Jack struggles to get used to his new surroundings, Ed helps him regain his confidence on and off the field.

Louis, a terminally ill writer, returns home after a long absence to tell his family that he is dying.