An orphan in a facility run by the mean Miss Hannigan, Annie believes that her parents left her there by mistake. When a rich man named Oliver "Daddy" Warbucks decides to let an orphan live at his home to promote his image, Annie is selected. While Annie gets accustomed to living in Warbucks' mansion, she still longs to meet her parents. So Warbucks announces a search for them and a reward, which brings out many frauds.

Five years after they defeated Gozer, the Ghostbusters are out of business. When Dana begins to have ghost problems again, the boys come out of retirement to aid her and hopefully save New York City from a new paranormal threat.

When Longfellow Deeds, a small-town pizzeria owner and poet, inherits $40 billion from his deceased uncle, he quickly begins rolling in a different kind of dough. Moving to the big city, Deeds finds himself besieged by opportunists all gunning for their piece of the pie. Babe, a television tabloid reporter, poses as an innocent small-town girl to do an exposé on Deeds.

Coogan, an Arizona deputy sheriff goes to New York to pick up a prisoner. While escorting the prisoner to the airport, he escapes and Coogan heads into the city to recapture him.

New York police are bemused by reports of a giant flying lizard that has been spotted around the rooftops of New York, until the lizard starts to eat people. An out-of-work ex-con is the only person who knows the location of the monster's nest and is determined to turn the knowledge to his advantage, but will his gamble pay off or will he end up as lizard food?

Lester and Orville accidentally launch a rocket which is supposed to fly to Mars. Instead it goes to New Orleans for Mardi Gras. They are then forced by bank robber Mugsy and his pal Harry to fly to Venus where they find a civilization made up entirely of women, men having been banished.