During a stopover in Germany in the middle of a carefree road trip through Europe, two American girls find themselves alone at night when their car breaks down in the woods. Searching for help at a nearby villa, they are wooed into the clutches of a deranged retired surgeon who explains his mad scientific vision to his captives' utter horror. They are to be the subjects of his sick lifetime fantasy: to be the first to connect people, one to the next, and in doing so bring to life "the human centipede."

A detective and a medical examiner join forces to solve a series of horrific murders in Victorian London - but one of them harbors a deadly secret.

Medical student Paula wins a place at an exclusive Heidelberg medical school. When the body of a young man she met on the train turns up on her dissection table, she begins to investigate the mysterious circumstances surrounding his death.

The doctor and soccer player in the leisure time Jo Hauser decides to move to Berlin and be an intern in a famous clinic, expecting to increase his knowledge and expertize, and help his handicap brother Willi Hauser. He joins a secret fraternity of doctors, under the leadership of Prof. Muller-LaRousse, who is researching the use of bionic muscles in human beings without any ethics or respect to the laws. The team is also volunteer to the experiences, and is under investigation of Paula Henning. When Jo gets close to a Filipino nurse, and becomes addicted in the drugs used in experience, he realizes the truth hidden in the methods used by the secret society in the development of science.

A wisecracking New York reporter intrudes on a research scientist's quest to unmask The Moon Killer.

A young doctor is suspected when a series of Jack the Ripper copycat killings is committed. However, when the doctor himself is murdered, his identical twin brother claims to have seen visions of the true killer.