Clear the runway for Derek Zoolander, VH1's three-time male model of the year. His face falls when hippie-chic Hansel scooters in to steal this year's award. The evil fashion guru Mugatu seizes the opportunity to turn Derek into a killing machine. It's a well-designed conspiracy and only with the help of Hansel and a few well-chosen accessories like Matilda can Derek make the world safe for male models everywhere.

The naive Evelyn Warren, elected school teacher of the year by Time Magazine, goes to Las Vegas, where she loses a lot of money. In order to pay her debts, casino manager Matt Braddock asks her to take care of his sad little daughter Diana.