Marcus Burnett is a henpecked family man. Mike Lowry is a footloose and fancy free ladies' man. Both Miami policemen, they have 72 hours to reclaim a consignment of drugs stolen from under their station's nose. To complicate matters, in order to get the assistance of the sole witness to a murder, they have to pretend to be each other.

Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.

In Paris, Lulu, a passionate policeman, works with the faith of a rookie, despite the sclerotic bureaucracy and the incompetence or negligence of some of his colleagues. In his new position as a narcotics inspector, he tries to keep his sanity as he witnesses the worst of the human condition.

A narcotics detective, played by Fred Williamson, lets nothing stand in the way of his bringing down a major drug dealer. After a bust gone awry, he's accused of stealing a lost briefcase filled with money and both the mob and the police are looking for him. A ruthless hit man, played by Bruce Glover, will stop at nothing to get what his boss wants; the money!

“Use Your Eyes” is a police training film produced by the Alhambra Police Department, California, in 1970. It is intended to demonstrate to police officers how to search a residence for evidence of marijuana use, and what rights they have to search the property once certain prima facia evidence is established.

Ryan of the DEA will face again the most dangerous drug lord of Venezuela, this time with new friends, in 1983.