Over the course of three days Ross, a college dropout addicted to crystal-meth, encounters a variety of oddball folks - including a stripper named Nikki and her boyfriend, the local meth producer, The Cook - but all he really wants to do is hook up with his old girlfriend, Amy.

Remy is a medical student who has a flair for making his patients comfortable. His genuine concern for the patients in his charge marks him as a hot prospect in his internship program. Pamela works at a children's book publishing company. The two meet via Pamela's brother, who is also Remy's good friend. They fall in love and get an apartment in the East Village of New York. Soon after, the couple begins to indulge in speed and barbiturates. They become heavily addicted. Remy is thrown out of medical school and Pamela quits her job. Remy soon finds himself in debt with the local dealer, Stutter, who introduces his customer to heroin as a revenge for his late bill. Pamela faces the prospect of getting sober at her brother's clinic, but must leave behind a destitute Remy in order to do it.

After stealing a huge stash of drugs, speed freaks Hector and Dorena plan to cook up an enormous batch of crystal meth and get rich quick. Hector's old buddy Merle has the perfect hideout/meth lab: an old, abandoned farmhouse in the woods where no one will ever find them. Unfortunately, no one will hear their screams either. Turns out, they may not be alone after all. It seems this farmhouse is the site of a horrific urban legend. Now, holed up together with nothing to do but snort, smoke and shoot up, the strung-out "cookers" fall prey to paranoia, private demons and terrifying visions which, whether they are hallucinations or hauntings, are equally terrifying and just as deadly!