Psycho-Pass is set in a futuristic era in Japan where the Sibyl System, a powerful network of psychometric scanners, actively measures the biometrics of its citizens' minds. The resulting assessment is called a Psycho-Pass. When the calculated likelihood of an individual committing a crime, measured by the Crime Coefficient index, exceeds an accepted threshold, he or she is pursued, apprehended, and either arrested or decomposed by the field officers of the Crime Investigation Department of the Public Safety Bureau.

Cel mai puternic supererou din lume poate ucide pe oricine cu o singură lovitură. Dar nu are parte de nicio provocare, așa că se luptă cu plictiseala și cu depresia.