Catherine Black is a world-famous neurologist at the state-of-the-art medical institution known as "The Cube". Catherine is brilliant, beautiful, and at the top of her game, though she's hiding a secret of her own: she's bipolar. Each week, the doctors on staff attempt to unravel the mysteries of the brain and are constantly challenged by cases never-before-seen on television. The medical stories are moving, bizarre and a visual feast. The personal stories are riveting. The patients have rare, highly visual, often hallucinogenic and startling conditions, which we’ll see through their eyes as Catherine diagnoses and treats them.

In 2052, a Nobel Prize-winning neuroscientist develops a drug called Hapuna — a cure-all that has the unexpected side-effect of causing death three years later. In response to this threat, a special force of agents—nicknamed "Lazarus"— is assembled to take on the malevolent Skinner.