An American investigator for the U.N., a German scientist and a British reporter join forces to investigate a series of disappearances and mutilation-deaths confined to a Swiss Alp and involving a thick, mobile cloud, a telepathic girl, an animate dead man, and tentacled, cyclopean beings from another planet.

In a world ravaged by a rabies virus that turns people into hungry cannibals, Alice a pregnant survivor, along with two other men, struggles to reach an island unaffected by the plague. Meanwhile a dangerous man is on the trail of a mysterious girl, and Alice soon discovers that zombies are not the only threat.

In a dark subterranean landscape, the Amphibian has lost its way.