It focuses on two friends, one of whom pursues a relationship with a mysterious woman who part owns a guest house and who he has been dating online. Problems occur when guests at the isolated guest house begin to disappear and the guys discover the truth about the woman and her monstrous sisters and how they must escape from a mysterious island if they want to survive beyond dawn.

Set in rural Nebraska following the First World War, six veterans on motorcycles ride into the sleepy little town of Bingo. The locals are friendly until one of the vets beats a local kid in a drag race, after which the six are driven out of town. After coming upon a small farm, the fugitives are allowed to hide out by the two sisters who run the place. Things go smoothly until one of the vets, after smoking the locoweed growing nearby, tries to rape one of the hosts. Being part Native American, her sister decides to get revenge by casting a hex that steadily does in each of the unwelcome guests.

At age 50, tax inspector Emerenziano decides to settle down and aims to the three Tettamanzi sisters, who, though not young or pretty by any means, have recently inherited a large amount of money.