A woman, accidentally caught in a dark deal, turns the tables on her captors and transforms into a merciless warrior evolved beyond human logic.

Two New Orleans paramedics' lives are ripped apart after encountering a series of horrific deaths linked to a designer drug with bizarre, otherworldly effects.

Mark 13 is a government-built killing machine programmed with artificial intelligence, able to repair and recharge itself from any energy source. Through a series of coincidences, the cyborg's head ends up in the home of a sculptress as a bizarre Christmas present from her boyfriend. Once inside its new home, the cyborg promptly reconstructs the rest of its body using a variety of household utensils and proceeds to go on a murderous rampage.