In Arborville, California, three high school students try to protect their hometown from a gelatinous alien life form that engulfs everything it touches. The first to discover the substance and live to tell about it, the trio witness the Blob destroying an elderly man, then it growing to a terrifying size. But no one else has seen the goo, and the police refuse to believe the kids without proof.

A group of hobos begin melting into multicolored piles of goo after drinking sixty-year-old liquor. At the same time, the psychotic Vietnam War vet who rules the hobo camp snaps and begins killing at random. Two brothers set out to stop the liquor and the killer.